METHODS: Urban arboviruses DENV, ZIKV and CHIKV were investigated in blood donations (n = 778) at the State Institute of Hematology, HEMORIO (RJ) from 2019 to 2022 by serological and molecular methods.
RESULTS: An overall arbovirus exposure was observed in 26.1% of the blood donations. Anti-DENV IgM was detected in 4.0% of samples and two donations were DENV NS1 positive. Positive anti-CHIKV IgM was observed in 4.7% of the donations. Co-detection of anti-CHIKV IgM and anti-DENV IgM was observed in 1.0% of donors, and CHIKV prevalence was 21.3%. All blood donations tested were negative for the DENV, ZIKV and CHIKV RNA.
CONCLUSIONS: IgM seroprevalence to the arboviruses analyzed here is an indicator of recent infection in asymptomatic donors, showing that the population of blood donors can be a vehicle for new infections, especially during epidemic periods.
方法:城市虫媒病毒DENV,ZIKV和CHIKV在国家血液研究所进行了献血调查(n=778),通过血清学和分子方法,从2019年到2022年的HMORIO(RJ)。
结果:在26.1%的献血者中观察到总体虫媒病毒暴露。在4.0%的样品中检测到抗DENVIgM,两个捐赠为DENVNS1阳性。在4.7%的捐赠中观察到阳性抗CHIKVIgM。在1.0%的供体中观察到抗CHIKVIgM和抗DENVIgM的共检测,CHIKV患病率为21.3%。所有检测的献血都是DENV阴性,ZIKV和CHIKVRNA。
结论:本文分析的IgM对虫媒病毒的血清阳性率是无症状供体近期感染的指标,表明献血者可以成为新感染的载体,尤其是在流行期间。