PDF(Pubmed)
Abstract：
BACKGROUND: Restrictive anorexia nervosa (AN) is associated with distorted perception of body shape, previously linked to hypoactivity and reduced excitability of the right inferior parietal lobe (rIPL). Here, we investigated the impact of high-frequency repetitive transcranial magnetic stimulation (HF rTMS) of the rIPL on body shape perception in patients with AN.
METHODS: Seventeen patients with AN (median [Q1_Q3] age, 35 [27_39] years; disease duration, 12 [6_18] years) were randomly assigned to receive real or sham HF (10 Hz) rTMS of the rIPL over a period of 2 weeks, comprising 10 sessions. The primary outcome measure was the Body Shape Questionnaire (BSQ). Secondary outcomes included eating disorder symptoms, body mass index, mood, anxiety, and safety. Data collection were done at baseline, post-rTMS, and at 2 weeks and 3 months post-rTMS.
RESULTS: Following both real and sham rTMS of the rIPL, no significant differences were observed in body shape perception or other parameters. Both real and sham rTMS interventions were deemed safe and well tolerated. Notably, serious adverse events were associated with the underlying eating and mood disorders, resulting in hospitalization for undernutrition (five patients) or suicidal attempts (two patients).
CONCLUSIONS: This pilot study does not support the use of rTMS of the rIPL as an effective method for improving body shape perception in individuals with the restrictive form of AN. Further research is warranted to comprehensively explore both the clinical and neurophysiological effects of HF rTMS in this population.
METHODS: Seventeen patients with AN (median [Q1_Q3] age, 35 [27_39] years; disease duration, 12 [6_18] years) were randomly assigned to receive real or sham HF (10 Hz) rTMS of the rIPL over a period of 2 weeks, comprising 10 sessions. The primary outcome measure was the Body Shape Questionnaire (BSQ). Secondary outcomes included eating disorder symptoms, body mass index, mood, anxiety, and safety. Data collection were done at baseline, post-rTMS, and at 2 weeks and 3 months post-rTMS.
RESULTS: Following both real and sham rTMS of the rIPL, no significant differences were observed in body shape perception or other parameters. Both real and sham rTMS interventions were deemed safe and well tolerated. Notably, serious adverse events were associated with the underlying eating and mood disorders, resulting in hospitalization for undernutrition (five patients) or suicidal attempts (two patients).
CONCLUSIONS: This pilot study does not support the use of rTMS of the rIPL as an effective method for improving body shape perception in individuals with the restrictive form of AN. Further research is warranted to comprehensively explore both the clinical and neurophysiological effects of HF rTMS in this population.
摘要：
背景：限制性神经性厌食症（AN）与对身体形状的扭曲感知有关，先前与右下顶叶（rIPL）的活动不足和兴奋性降低有关。这里,我们调查了rIPL的高频重复经颅磁刺激(HFrTMS)对AN患者体形感知的影响.
方法：17名AN患者（中位[Q1_Q3]年龄，35[27_39]年；疾病持续时间，12[6_18]年）被随机分配在2周内接受rIPL的真实或假HF（10Hz）rTMS，包括10个会议。主要结果指标是身体形态问卷（BSQ）。次要结果包括进食障碍症状，身体质量指数,心情,焦虑,和安全。在基线时进行数据收集，rTMS后，rTMS后2周和3个月。
结果：在rIPL的真实和假rTMS之后，在体形感知或其他参数方面没有观察到显着差异。真实和假rTMS干预均被认为是安全且耐受性良好的。值得注意的是,严重不良事件与潜在的饮食和情绪障碍有关，导致住院营养不良（5例）或自杀未遂（2例）。
结论：这项初步研究不支持使用rIPL的rTMS作为一种有效的方法来改善具有限制性形式AN的个体的身体形状感知。需要进一步的研究来全面探索HFrTMS在该人群中的临床和神经生理作用。
方法：17名AN患者（中位[Q1_Q3]年龄，35[27_39]年；疾病持续时间，12[6_18]年）被随机分配在2周内接受rIPL的真实或假HF（10Hz）rTMS，包括10个会议。主要结果指标是身体形态问卷（BSQ）。次要结果包括进食障碍症状，身体质量指数,心情,焦虑,和安全。在基线时进行数据收集，rTMS后，rTMS后2周和3个月。
结果：在rIPL的真实和假rTMS之后，在体形感知或其他参数方面没有观察到显着差异。真实和假rTMS干预均被认为是安全且耐受性良好的。值得注意的是,严重不良事件与潜在的饮食和情绪障碍有关，导致住院营养不良（5例）或自杀未遂（2例）。
结论：这项初步研究不支持使用rIPL的rTMS作为一种有效的方法来改善具有限制性形式AN的个体的身体形状感知。需要进一步的研究来全面探索HFrTMS在该人群中的临床和神经生理作用。
