An open-label, randomized, non-inferiority trial of the efficacy and safety of ciprofloxacin versus an aminoglycoside + ciprofloxacin in the treatment of bubonic plague (IMASOY): study protocol for a randomized control trial-an update to the published protocol.

一个开放的标签 ，随机化 ，环丙沙星与氨基糖苷 + 环丙沙星治疗鼠疫疗效和安全性的非劣效性试验 (IMASOY): 一项随机对照试验的研究方案 - 对已发表方案的更新.

• 影响指数: 2.728
• 发表时间: 2024 Jul 5
• 来源期刊: Trials
• DOI: 10.1186/s13063-024-08302-7
• PMID: 38970065
• 文章类型: Clinical Trial Protocol
• 中科院分区: Q3
• 方向: 医学
• 作者列表: Randremanana RV,Raberahona M,de Dieu Randria MJ,Bourner J,Zadonirina G,Razananaivo H,Mayouya-Gamana T,Mangahasimbola R,Pesonel E,Gillesen A,Rajerison M,Andrianaivoarimanana V,Edwards T,Horby P,Olliaro P

Mesh: Ciprofloxacin / adverse effects administration & dosage therapeutic use; Treatment Outcome; Humans; Anti-Bacterial Agents / adverse effects administration & dosage therapeutic use; Plague / drug therapy; Randomized Controlled Trials as Topic; Equivalence Trials as Topic; Drug Therapy, Combination; Animals; Aminoglycosides / adverse effects administration & dosage therapeutic use

Abstract

This article reports an update to the protocol of the IMASOY trial, which was prospectively registered on clinicaltrials.gov (NCT04110340) in October 2019.

摘要

本文报告了IMASOY试验协议的更新，2019年10月在clinicaltrials.gov（NCT04110340）上进行了前瞻性注册。