关键词: Apoptosis Breast cancer Cervical cancer miRNA

来  源:   DOI:10.1007/s12013-024-01405-7

Abstract:
In today\'s world, one of the main problems is cancer, which still has a long way to go to cure it, and it brings a lot of financial and emotional costs to the people of society and governments. Breast cancer (BC) and cervical cancer (CC), two of the most common cancers, are caused by several genetic and environmental factors in women. These two cancers\' involvement rate is higher than other cancers in women. microRNAs (miRNAs) are non-coding RNA molecules with a length of 18 to 24 nucleotides, which play an important role in post-translational changes. miRNAs themselves are divided into two categories, oncomiRs and tumor suppressors. OncomiRs have a part in tumor expansion and tumor suppressors prevent tumor development and progress. miRNAs can control cellular processes by regulating various pathways including autophagy, apoptosis, and signaling. Apoptosis is a type of programmed cell death that includes intrinsic and extrinsic pathways and is different from other cell death pathways such as necrosis and ferroptosis. Apoptosis controls the growth, differentiation, and death of cells by regulating the death of damaged and old cells, and since miRNAs are one of the factors that regulate apoptosis, and divided into two categories: pro-apoptotic and anti-apoptotic. We decided in this study to investigate the relationship between miRNAs and apoptosis in the most common women\'s cancers, BC and CC.
摘要:
在当今世界,主要问题之一是癌症,要治愈它还有很长的路要走,它给社会和政府带来了很多财政和情感成本。乳腺癌(BC)和宫颈癌(CC),两种最常见的癌症,是由女性的几种遗传和环境因素引起的。这两种癌症的受累率高于女性的其他癌症。microRNAs(miRNAs)是一种长度为18到24个核苷酸的非编码RNA分子,在翻译后的变化中起着重要的作用。miRNA本身分为两类,肿瘤抑制因子和肿瘤抑制因子。OncomiRs在肿瘤扩张和肿瘤抑制剂中具有部分作用,可阻止肿瘤的发展和进展。miRNA可以通过调节包括自噬在内的各种途径来控制细胞过程,凋亡,和信号。细胞凋亡是一种程序性细胞死亡,包括内在和外在途径,不同于其他细胞死亡途径,如坏死和铁死亡。细胞凋亡控制生长,分化,通过调节受损细胞和旧细胞的死亡,由于miRNAs是调节细胞凋亡的因子之一,分为两类:促凋亡和抗凋亡。在这项研究中,我们决定在最常见的女性癌症中研究miRNAs与细胞凋亡之间的关系。BC和CC。
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