PDF(Pubmed)
Abstract：
The extracellular matrix (ECM) is a dynamic set of molecules produced by the cellular component of normal and pathological tissues of the embryo and adult. ECM acts as critical regulator in various biological processes such as differentiation, cell proliferation, angiogenesis, and immune control. The most frequent primary brain tumors are gliomas and by far the majority are adult astrocytic tumors (AATs). The prognosis for patients with these neoplasms is poor and the treatments modestly improves survival. In the literature, there is a fair number of studies concerning the composition of the ECM in AATs, while the number of studies relating the composition of the ECM with the immune regulation is smaller. Circulating ECM proteins have emerged as a promising biomarker that reflect the general immune landscape of tumor microenvironment and may represent a useful tool in assessing disease activity. Given the importance it can have for therapeutic and prognostic purposes, the aim of our study is to summarize the biological properties of ECM components and their effects on the tumor microenvironment and to provide an overview of the interactions between major ECM proteins and immune cells in AATs. As the field of immunotherapy in glioma is quickly expanding, we retain that current data together with future studies on ECM organization and functions in glioma will provide important insights into the tuning of immunotherapeutic approaches.
摘要：
细胞外基质（ECM）是由胚胎和成人的正常和病理组织的细胞成分产生的一组动态分子。ECM在各种生物过程中充当关键调节剂，如分化，细胞增殖，血管生成,和免疫控制。最常见的原发性脑肿瘤是神经胶质瘤，到目前为止，大多数是成人星形细胞肿瘤（AAT）。这些肿瘤患者的预后较差，治疗可适度提高生存率。在文学中,关于AATs中ECM组成的研究相当多，而将ECM的组成与免疫调节相关的研究数量较少。循环ECM蛋白已成为一种有前途的生物标志物，可反映肿瘤微环境的总体免疫状况，并可能成为评估疾病活动的有用工具。鉴于它对治疗和预后目的的重要性，我们的研究目的是总结ECM成分的生物学特性及其对肿瘤微环境的影响，并概述AATs中主要ECM蛋白与免疫细胞之间的相互作用。随着神经胶质瘤免疫治疗领域的迅速扩大，我们认为,目前的数据以及未来关于神经胶质瘤ECM组织和功能的研究将为调整免疫治疗方法提供重要的见解.
