Abstract：
OBJECTIVE: To determine the effectiveness of picosecond KTP in reducing peri-ocular dark circles caused mainly by excessive pigmentation and to compare Picosecond KTP with Thulium laser ability in reducing the intensity and extent of peri-ocular dark circles.
METHODS: This split-face prospective study included twelve women with periorbital dark circles (pigmented or mixed-pigmented type). The left lower eyelid was treated using the PicoHi machine (HIRONIC Ltd), a full beam Q-switched Nd-YAG provided by KTP crystal (523 nm) at settings of 0.3 J/cm2, 5 mm, 5 Hz, and 300 Ps. Whereas the right lower eyelid was treated using the Lavieen machine (WON TECH Co., Ltd), a fractional Thulium laser (1927 nm) at setting 1320 mJ/cm2, 30 × 15 mm, 1500 microseconds. Patients received a series of 3 treatment sessions, given at 4-week intervals.
RESULTS: The 532-nm full beam Q-switched KTP and fractional Thulium lasers were more likely to induce post-inflammatory hyperpigmentation rather than decrease the pigmentation. The risk is higher with a Q-switched KTP laser, which may be attributed to the skin tone of the participants. Nonetheless, some improvement in the pigmented type of PDCs, although not detected clinically, was documented by the VISIA software.
CONCLUSIONS: No solid conclusion can be drawn from the results of the study. Picosecond KTP and Thulium lasers may have a role in reducing PDCs yet more studies should be performed in order to determine the exact impact these lasers have.
METHODS: This split-face prospective study included twelve women with periorbital dark circles (pigmented or mixed-pigmented type). The left lower eyelid was treated using the PicoHi machine (HIRONIC Ltd), a full beam Q-switched Nd-YAG provided by KTP crystal (523 nm) at settings of 0.3 J/cm2, 5 mm, 5 Hz, and 300 Ps. Whereas the right lower eyelid was treated using the Lavieen machine (WON TECH Co., Ltd), a fractional Thulium laser (1927 nm) at setting 1320 mJ/cm2, 30 × 15 mm, 1500 microseconds. Patients received a series of 3 treatment sessions, given at 4-week intervals.
RESULTS: The 532-nm full beam Q-switched KTP and fractional Thulium lasers were more likely to induce post-inflammatory hyperpigmentation rather than decrease the pigmentation. The risk is higher with a Q-switched KTP laser, which may be attributed to the skin tone of the participants. Nonetheless, some improvement in the pigmented type of PDCs, although not detected clinically, was documented by the VISIA software.
CONCLUSIONS: No solid conclusion can be drawn from the results of the study. Picosecond KTP and Thulium lasers may have a role in reducing PDCs yet more studies should be performed in order to determine the exact impact these lasers have.
摘要：
目的：确定皮秒KTP在减少主要由过度色素沉着引起的眼周黑眼圈中的有效性，并比较皮秒KTP与Thulium激光在减少眼周黑眼圈的强度和程度方面的能力。
方法：这项分脸前瞻性研究包括12名眶周黑眼圈（色素沉着型或混合色素沉着型）的女性。使用PicoHi机器（HIRONICLtd）治疗左下眼睑，由KTP晶体（523nm）提供的全光束调QNd-YAG，设置为0.3J/cm2，5mm，5Hz,300ps而右下眼睑是使用Laveen机器治疗的(WONTECHCo.，Ltd),设置为1320mJ/cm2，30×15mm的分数Thulium激光（1927nm），1500微秒。患者接受了一系列3次治疗，每隔4周给予一次。
结果：532nm全光束Q开关KTP和分数激光更有可能诱发炎症后色素沉着过度，而不是减少色素沉着。Q开关KTP激光器的风险更高，这可能归因于参与者的肤色。尽管如此，色素沉着型PDC的一些改进，虽然临床上没有发现，由VISIA软件记录。
结论：从研究结果中无法得出可靠的结论。皮秒KTP和Thulium激光器可能在减少PDC中起作用，但应进行更多研究以确定这些激光器的确切影响。
方法：这项分脸前瞻性研究包括12名眶周黑眼圈（色素沉着型或混合色素沉着型）的女性。使用PicoHi机器（HIRONICLtd）治疗左下眼睑，由KTP晶体（523nm）提供的全光束调QNd-YAG，设置为0.3J/cm2，5mm，5Hz,300ps而右下眼睑是使用Laveen机器治疗的(WONTECHCo.，Ltd),设置为1320mJ/cm2，30×15mm的分数Thulium激光（1927nm），1500微秒。患者接受了一系列3次治疗，每隔4周给予一次。
结果：532nm全光束Q开关KTP和分数激光更有可能诱发炎症后色素沉着过度，而不是减少色素沉着。Q开关KTP激光器的风险更高，这可能归因于参与者的肤色。尽管如此，色素沉着型PDC的一些改进，虽然临床上没有发现，由VISIA软件记录。
结论：从研究结果中无法得出可靠的结论。皮秒KTP和Thulium激光器可能在减少PDC中起作用，但应进行更多研究以确定这些激光器的确切影响。
