关键词: CXCR4 Lymphoma Molecular imaging Oncologic imaging PET

来  源:   DOI:10.1016/j.cpet.2024.05.002

Abstract:
While functional imaging with [18F]Fluoro-deoxy-glucose positron emission tomography (PET)/computed tomography is a well-established imaging modality in most lymphoma entities, novel tracers addressing cell surface receptors, tumor biology, and the microenvironment are being developed. Especially, with the emergence of immuno-PET targeting surface markers of lymphoma cells, a new imaging modality of immunotherapies is evolving, which might especially aid in relapsed and refractory disease stages. This review highlights different new PET tracers in indolent and aggressive lymphoma subtypes and summarizes the current state of immuno-PET imaging in lymphoma.
摘要:
虽然使用[18F]氟脱氧葡萄糖正电子发射断层扫描(PET)/计算机断层扫描的功能成像是大多数淋巴瘤实体中公认的成像方式,针对细胞表面受体的新型示踪剂,肿瘤生物学,微环境正在开发中。尤其是,随着免疫PET靶向淋巴瘤细胞表面标志物的出现,一种新的免疫疗法成像模式正在发展,这可能特别有助于复发和难治性疾病阶段。这篇综述重点介绍了惰性和侵袭性淋巴瘤亚型中不同的新PET示踪剂,并总结了淋巴瘤中免疫PET成像的现状。
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