Abstract：
Bioelectronics, a field pivotal in monitoring and stimulating biological processes, demands innovative nanomaterials as detection platforms. Two-dimensional (2D) materials, with their thin structures and exceptional physicochemical properties, have emerged as critical substances in this research. However, these materials face challenges in biomedical applications due to issues related to their biological compatibility, adaptability, functionality, and nano-bio surface characteristics. This review examines surface modifications using covalent and non-covalent-based polymer-functionalization strategies to overcome these limitations by enhancing the biological compatibility, adaptability, and functionality of 2D nanomaterials. These surface modifications aim to create stable and long-lasting therapeutic effects, significantly paving the way for the practical application of polymer-functionalized 2D materials in biosensors and bioelectronics. The review paper critically summarizes the surface functionalization of 2D nanomaterials with biocompatible polymers, including g-C3N4, graphene family, MXene, BP, MOF, and TMDCs, highlighting their current state, physicochemical structures, synthesis methods, material characteristics, and applications in biosensors and bioelectronics. The paper concludes with a discussion of prospects, challenges, and numerous opportunities in the evolving field of bioelectronics.
摘要：
生物电子学,一个监测和刺激生物过程的关键领域，需要创新的纳米材料作为检测平台。二维（2D）材料，它们的薄结构和特殊的物理化学性质，已经成为这项研究中的关键物质。然而,由于与生物相容性相关的问题，这些材料在生物医学应用中面临挑战，适应性，功能，和纳米生物表面特性。这篇综述研究了使用基于共价和非共价的聚合物功能化策略的表面修饰，以通过增强生物相容性来克服这些限制。适应性，和二维纳米材料的功能。这些表面修饰旨在创造稳定和持久的治疗效果。为聚合物功能化二维材料在生物传感器和生物电子学中的实际应用铺平了道路。评论论文批判性地总结了具有生物相容性聚合物的2D纳米材料的表面功能化，包括g-C3N4，石墨烯家族，MXene,BP,MOF,和TMDC，突出他们目前的状态，物理化学结构，合成方法，材料特性,以及在生物传感器和生物电子学中的应用。本文最后讨论了前景，挑战,以及不断发展的生物电子学领域的众多机会。
