PDF(Pubmed)
Abstract：
BACKGROUND: Climate change increases not only the frequency, intensity and duration of extreme heat events but also annual temperatures globally, resulting in many negative health effects, including harmful effects on pregnancy and pregnancy outcomes. As temperatures continue to increase precipitously, there is a growing need to understand the underlying biological pathways of this association. This systematic review will focus on maternal, placental and fetal changes that occur in pregnancy due to environmental heat stress exposure, in order to identify the evidence-based pathways that play a role in this association.
METHODS: We will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We will search PubMed and Ovid Embase databases from inception using tested and validated search algorithms. Inclusion of any studies that involve pregnant women and have measured environmental heat stress exposure and either maternal, placental or fetal physiological or biochemical changes and are available in English. Modelling studies or those with only animals will be excluded. The risk of bias will be assessed using the Office of Health Assessment and Translation tool. Abstract screening, data extraction and risk of bias assessment will be conducted by two independent reviewers.Environmental parameters will be reported for each study and where possible these will be combined to calculate a heat stress indicator to allow comparison of exposure between studies. A narrative synthesis will be presented following standard guidelines. Where outcome measures have at least two levels of exposure, we will conduct a dose-response meta-analysis should there be at least three studies with the same outcome. A random effects meta-analysis will be conducted where at least three studies give the same outcome.
BACKGROUND: This systematic review and meta-analysis does not require ethical approval. Dissemination will be through peer-reviewed journal publication and presentation at international conferences/interest groups.
UNASSIGNED: CRD42024511153.
METHODS: We will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We will search PubMed and Ovid Embase databases from inception using tested and validated search algorithms. Inclusion of any studies that involve pregnant women and have measured environmental heat stress exposure and either maternal, placental or fetal physiological or biochemical changes and are available in English. Modelling studies or those with only animals will be excluded. The risk of bias will be assessed using the Office of Health Assessment and Translation tool. Abstract screening, data extraction and risk of bias assessment will be conducted by two independent reviewers.Environmental parameters will be reported for each study and where possible these will be combined to calculate a heat stress indicator to allow comparison of exposure between studies. A narrative synthesis will be presented following standard guidelines. Where outcome measures have at least two levels of exposure, we will conduct a dose-response meta-analysis should there be at least three studies with the same outcome. A random effects meta-analysis will be conducted where at least three studies give the same outcome.
BACKGROUND: This systematic review and meta-analysis does not require ethical approval. Dissemination will be through peer-reviewed journal publication and presentation at international conferences/interest groups.
UNASSIGNED: CRD42024511153.
摘要：
背景：气候变化不仅增加了频率，极端高温事件的强度和持续时间，以及全球年气温，导致许多负面的健康影响，包括对妊娠和妊娠结局的有害影响。随着气温的急剧上升,越来越需要了解这种关联的潜在生物学途径。本系统综述将重点关注孕产妇，由于环境热应激暴露而在怀孕期间发生的胎盘和胎儿变化，为了确定在这种关联中起作用的循证途径。
方法：我们将遵循系统评价和荟萃分析指南的首选报告项目。我们将从一开始就使用经过测试和验证的搜索算法搜索PubMed和OvidEmbase数据库。包括任何涉及孕妇并测量环境热应激暴露和母亲的研究，胎盘或胎儿的生理或生化变化，有英文版本。建模研究或只有动物的研究将被排除。将使用健康评估和翻译工具办公室评估偏见的风险。抽象筛选,数据提取和偏见风险评估将由两名独立的审查员进行。将报告每个研究的环境参数，并在可能的情况下将这些参数结合起来计算热应力指标，以比较研究之间的暴露。将按照标准指南进行叙述性综合。如果结果衡量标准至少有两个暴露水平，如果至少有三项研究结果相同,我们将进行剂量-反应荟萃分析.将进行随机效应荟萃分析，其中至少三项研究得出相同的结果。
背景：本系统评价和荟萃分析不需要伦理批准。传播将通过同行评审的期刊出版和在国际会议/兴趣小组上的介绍。
■CRD42024511153。
方法：我们将遵循系统评价和荟萃分析指南的首选报告项目。我们将从一开始就使用经过测试和验证的搜索算法搜索PubMed和OvidEmbase数据库。包括任何涉及孕妇并测量环境热应激暴露和母亲的研究，胎盘或胎儿的生理或生化变化，有英文版本。建模研究或只有动物的研究将被排除。将使用健康评估和翻译工具办公室评估偏见的风险。抽象筛选,数据提取和偏见风险评估将由两名独立的审查员进行。将报告每个研究的环境参数，并在可能的情况下将这些参数结合起来计算热应力指标，以比较研究之间的暴露。将按照标准指南进行叙述性综合。如果结果衡量标准至少有两个暴露水平，如果至少有三项研究结果相同,我们将进行剂量-反应荟萃分析.将进行随机效应荟萃分析，其中至少三项研究得出相同的结果。
背景：本系统评价和荟萃分析不需要伦理批准。传播将通过同行评审的期刊出版和在国际会议/兴趣小组上的介绍。
■CRD42024511153。
