Abstract：
Although the associations between a patient\'s body mass index (BMI) and metabolic diseases, as well as their breath test results, have been studied, the relationship between breath hydrogen/methane levels and metabolic diseases needs to be further clarified. We aimed to investigate how the composition of exhaled breath gases relates to metabolic disorders, such as diabetes mellitus, dyslipidemia, hypertension, and nonalcoholic fatty liver disease (NAFLD), and their key risk factors. An analysis was performed using the medical records, including the lactulose breath test (LBT) data of patients who visited the Ajou University Medical Center, Suwon, Republic of Korea, between January 2016 and December 2021. The patients were grouped according to four different criteria for LBT hydrogen and methane levels. Of 441 patients, 325 (72.1%) had positive results for methane only (hydrogen < 20 parts per million [ppm] and methane ⩾ 3 ppm). BMIs and NAFLD prevalence were higher in patients with only methane positivity than in patients with hydrogen and methane positivity (hydrogen ⩾ 20 ppm and methane ⩾ 3 ppm). According to a multivariate analysis, the odds ratio of only methane positivity was 2.002 (95% confidence interval [CI]: 1.244-3.221,P= 0.004) for NAFLD. Our results demonstrate that breath methane positivity is related to NAFLD and suggest that increased methane gas on the breath tests has the potential to be an easily measurable biomarker for NAFLD diagnosis.
摘要：
尽管已经研究了体重指数（BMI）水平与代谢疾病之间的关联以及呼气测试结果与BMI水平之间的关联，呼吸氢/甲烷水平与代谢性疾病之间的关系需要进一步阐明。这项研究旨在调查呼出气体的成分与代谢紊乱及其关键危险因素的关系。BMI水平升高显着增加患代谢性疾病的风险；将其纳入本研究以发现它们的关联。糖尿病,血脂异常,高血压,非酒精性脂肪性肝病（NAFLD）是本研究的代谢性疾病。＆＃xD;对医疗记录进行了分析，包括访问Ajou大学医学中心的患者的乳果糖呼气试验（LBT）数据，水原,大韩民国,2016年1月至2021年12月。根据LBT氢和甲烷水平的四个不同标准对受试者进行分组：1）正常（N）（氢<20ppm，甲烷<3ppm）；2）仅氢（H）（氢≥20ppm，甲烷<3ppm）；3）甲烷阳性（M）（氢<20ppm，甲烷≥3ppm）；4）甲烷和氢阳性（M/H≥3ppm）（氢≥3ppm。在441个科目中，325(72.1%)仅对甲烷(M+)有阳性结果。具有M+的受试者的BMI和NAFLD的患病率高于具有氢和甲烷阳性(H+/M+)的受试者。根据多变量分析，NAFLD的M+比值比(OR)为2.002(95%CI:1.244-3.221,P=0.004).我们的结果表明，呼吸甲烷阳性与NAFLD有关，并表明呼吸测试中甲烷气体的增加有可能成为诊断NAFLD的易于测量的生物标志物。
.
