Abstract：
Chronic lung disease, also known as bronchopulmonary dysplasia affects thousands of infants worldwide each year. The impact on resources is second only to bronchial asthma, with lung function affected well into adolescence. Diagnostic and therapeutic constructs have almost exclusively focussed on pulmonary architecture (alveoli/airways) and pulmonary hypertension. Information on systemic hemodynamics indicates major artery thickness/stiffness, elevated systemic afterload and/or primary left ventricular dysfunction may play a part in a subset of infants with severe neonatal-pediatric lung disease. Understanding the underlying principles with attendant effectors would aid in identifying the pathophysiological course where systemic afterload reduction with angiotensin converting enzyme inhibitors could become the preferred treatment strategy over conventional pulmonary artery vasodilatation.
摘要：
慢性肺病,也被称为支气管肺发育不良每年影响全世界成千上万的婴儿。对资源的影响仅次于支气管哮喘，肺功能影响到青春期。诊断和治疗结构几乎完全集中于肺结构(肺泡/气道)和肺动脉高压。全身血流动力学信息显示大动脉厚度/硬度，全身后负荷升高和/或原发性左心室功能障碍可能在患有严重新生儿-儿科肺部疾病的婴儿亚组中发挥作用.了解伴随效应物的基本原理将有助于确定病理生理过程，其中使用血管紧张素转换酶抑制剂减少全身后负荷可能成为常规肺动脉舒张的首选治疗策略。
