Abstract：
OBJECTIVE: This study aimed to investigate the clinical and laboratory characteristics of salivary gland ultrasonography (SGUS)-positive patients with primary Sjögren\'s syndrome (pSS) compared to SGUS-negative patients and to analyse the diagnostic value of SGUS and labial salivary gland biopsy (LSGB) grading in pSS.
METHODS: A retrospective analysis of patients admitted to the Affiliated Hospital of Yangzhou University between May 2019 and November 2023 was conducted. According to the OMERACT scoring system, patients with pSS were divided into an SGUS-negative group (score <2) and an SGUS-positive group (score ≥2). The patient\'s age, gender, clinical symptoms, laboratory parameters and diagnostic examinations were compared and analysed, and Spearman correlation analysis was used to analyse the correlation between SGUS, LSGB and influencing factors.
RESULTS: There was no significant difference in dry mouth, dry eyes, tooth loss, fever, joint pain, fatigue, interstitial lung disease or renal tubular acidosis between the two groups, although there were more patients with salivary gland enlargement in the SGUS-positive group (p < 0.05). In terms of high levels of immunoglobulin G (IgG), high levels of rheumatoid factor (RF), anti-nuclear antibody ≥1:320, anti-Sjögren\'s syndrome A-52KD and anti-Sjögren\'s syndrome B, the number of cases in the SGUS-positive group was greater than that in the SGUS-negative group (p < 0.05). LSGB samples were graded per the Chisholm-Mason system with significant differences between multiple groups. SGUS score negatively correlated with age and positively correlated with LSGB grade.
CONCLUSIONS: This study showed that the SGUS score positively correlated with LSGB grade in pSS patients and negatively correlated with patient age. Thus, SGUS and LSGB are consistent in the diagnosis of pSS to reflect the degree of salivary gland involvement, and patients who are SGUS positive have high RF and IgG levels, a variety of autoantibodies positive and a tendency toward salivary gland enlargement.
METHODS: A retrospective analysis of patients admitted to the Affiliated Hospital of Yangzhou University between May 2019 and November 2023 was conducted. According to the OMERACT scoring system, patients with pSS were divided into an SGUS-negative group (score <2) and an SGUS-positive group (score ≥2). The patient\'s age, gender, clinical symptoms, laboratory parameters and diagnostic examinations were compared and analysed, and Spearman correlation analysis was used to analyse the correlation between SGUS, LSGB and influencing factors.
RESULTS: There was no significant difference in dry mouth, dry eyes, tooth loss, fever, joint pain, fatigue, interstitial lung disease or renal tubular acidosis between the two groups, although there were more patients with salivary gland enlargement in the SGUS-positive group (p < 0.05). In terms of high levels of immunoglobulin G (IgG), high levels of rheumatoid factor (RF), anti-nuclear antibody ≥1:320, anti-Sjögren\'s syndrome A-52KD and anti-Sjögren\'s syndrome B, the number of cases in the SGUS-positive group was greater than that in the SGUS-negative group (p < 0.05). LSGB samples were graded per the Chisholm-Mason system with significant differences between multiple groups. SGUS score negatively correlated with age and positively correlated with LSGB grade.
CONCLUSIONS: This study showed that the SGUS score positively correlated with LSGB grade in pSS patients and negatively correlated with patient age. Thus, SGUS and LSGB are consistent in the diagnosis of pSS to reflect the degree of salivary gland involvement, and patients who are SGUS positive have high RF and IgG levels, a variety of autoantibodies positive and a tendency toward salivary gland enlargement.
摘要：
目的：本研究旨在探讨唾液腺超声(SGUS)阳性的原发性干燥综合征(pSS)患者与SGUS阴性患者的临床和实验室特征,并分析SGUS和唇唾液腺活检(LSGB)分级在pSS中的诊断价值。
方法：对扬州大学附属医院2019年5月至2023年11月收治的患者进行回顾性分析。根据OMERACT评分系统，pSS患者分为SGUS阴性组(评分<2)和SGUS阳性组(评分≥2).病人的年龄,性别,临床症状,实验室参数和诊断检查进行了比较和分析，使用Spearman相关分析来分析SGUS之间的相关性，LSGB及其影响因素
结果：口干无显著差异，干眼,牙齿脱落,发烧,关节痛,疲劳,两组间的间质性肺病或肾小管性酸中毒,虽然SGUS阳性组唾液腺肿大患者较多(p<0.05)。在高水平的免疫球蛋白G（IgG）方面，高水平的类风湿因子（RF），抗核抗体≥1：320，抗干燥综合征A-52KD和抗干燥综合征B，SGUS阳性组病例数大于SGUS阴性组(p<0.05)。根据Chisholm-Mason系统对LSGB样品进行分级，多组之间存在显着差异。SGUS评分与年龄呈负相关,与LSGB分级呈正相关。
结论：这项研究表明，在pSS患者中，SGUS评分与LSGB分级呈正相关，与患者年龄呈负相关。因此，SGUS和LSGB在诊断pSS时是一致的，以反映唾液腺受累的程度，SGUS阳性的患者具有较高的RF和IgG水平，各种自身抗体阳性，唾液腺有肿大的趋势。
方法：对扬州大学附属医院2019年5月至2023年11月收治的患者进行回顾性分析。根据OMERACT评分系统，pSS患者分为SGUS阴性组(评分<2)和SGUS阳性组(评分≥2).病人的年龄,性别,临床症状,实验室参数和诊断检查进行了比较和分析，使用Spearman相关分析来分析SGUS之间的相关性，LSGB及其影响因素
结果：口干无显著差异，干眼,牙齿脱落,发烧,关节痛,疲劳,两组间的间质性肺病或肾小管性酸中毒,虽然SGUS阳性组唾液腺肿大患者较多(p<0.05)。在高水平的免疫球蛋白G（IgG）方面，高水平的类风湿因子（RF），抗核抗体≥1：320，抗干燥综合征A-52KD和抗干燥综合征B，SGUS阳性组病例数大于SGUS阴性组(p<0.05)。根据Chisholm-Mason系统对LSGB样品进行分级，多组之间存在显着差异。SGUS评分与年龄呈负相关,与LSGB分级呈正相关。
结论：这项研究表明，在pSS患者中，SGUS评分与LSGB分级呈正相关，与患者年龄呈负相关。因此，SGUS和LSGB在诊断pSS时是一致的，以反映唾液腺受累的程度，SGUS阳性的患者具有较高的RF和IgG水平，各种自身抗体阳性，唾液腺有肿大的趋势。
