Abstract：
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that impairs communication, socialization, and behavior. The association of ASD with folic acid has been investigated due to the importance of this vitamin for neurological health. This study is an update of the publication \'Folic acid and autism: What do we know?\' and aims to systematically review studies examining the relationship between folic acid and ASD. The search resulted in 2,389 studies on folic acid and ASD, which were selected by two reviewers based on their titles and abstracts. Studies meeting the inclusion criteria were fully read. The 52 included studies involved 10,429 individuals diagnosed with ASD and assessed the intake of vitamin B6, folic acid, and vitamin B12; serum levels of these vitamins, homocysteine, and methionine; therapeutic interventions using folic acid; and the association between maternal exposure to this vitamin and the risk of ASD. The evidence of insufficient folic acid intake in most individuals with ASD remains consistent in this update. No association was found between maternal exposure to folic acid and the risk of ASD in their children. Despite observed improvements in communication, socialization, and behavior in individuals with ASD following folic acid interventions, it is crucial to consider the individuality and complexity of ASD. Given the relevance of the topic, there remains a need for more high-quality research and clinical trials characterized by rigorous methodological designs.
摘要：
自闭症谱系障碍（ASD）是一种复杂的神经发育状况，会损害沟通，社会化,和行为。由于这种维生素对神经系统健康的重要性，已经研究了ASD与叶酸的关联。这项研究是对“叶酸与自闭症：我们知道什么？”出版物的更新，旨在系统地回顾研究叶酸与ASD之间关系的研究。这项搜索导致了2389项关于叶酸和ASD的研究，由两名审稿人根据他们的标题和摘要选择。充分阅读符合纳入标准的研究。纳入的52项研究涉及10,429名被诊断患有ASD的个体，并评估了维生素B6，叶酸，和维生素B12；这些维生素的血清水平，同型半胱氨酸,和蛋氨酸；使用叶酸的治疗干预措施；以及母体暴露于这种维生素与ASD风险之间的关系。大多数ASD患者叶酸摄入不足的证据在此更新中保持一致。未发现母亲接触叶酸与子女ASD风险之间存在关联。尽管观察到通信有所改善，社会化,以及叶酸干预后ASD患者的行为，考虑ASD的个性和复杂性至关重要。鉴于主题的相关性，仍然需要更多高质量的研究和临床试验，其特征是严格的方法学设计。
