Abstract：
The prior studies have shown that interleukin-2 (IL-2) exerts important roles in the pathological and physiological processes of lung diseases. However, the role of IL-2 in community-acquired pneumonia (CAP) is still uncertain. Through a prospective cohort study, our research will explore the correlations between serum IL-2 levels and the severity and prognosis in CAP patients. There were 267 CAP patients included. Blood samples were obtained. Serum IL-2 were tested by enzyme-linked immunosorbent assay (ELISA). Demographic traits and clinical characteristics were extracted. Serum IL-2 were gradually elevated with increasing severity scores in CAP patients. Correlation analyses revealed that serum IL-2 were connected with physiological parameters including liver and renal function in CAP patients. According to a logistic regression analysis, serum IL-2 were positively correlated with CAP severity scores. We also tracked the prognostic outcomes of CAP patients. The increased risks of adversely prognostic outcomes, including mechanical ventilation, vasoactive agent usage, ICU admission, death, and longer hospital length, were associated with higher levels of IL-2 at admission. Serum IL-2 at admission were positively associated with severe conditions and poor prognosis among CAP patients, indicated that IL-2 may involve in the initiation and development of CAP. As a result, serum IL-2 may be an available biomarker to guide clinicians in assessing the severity and determining the prognosis of CAP.
摘要：
先前的研究表明，白细胞介素-2（IL-2）在肺部疾病的病理和生理过程中发挥重要作用。然而,IL-2在社区获得性肺炎(CAP)中的作用尚不确定.通过一项前瞻性队列研究，本研究将探讨CAP患者血清IL-2水平与严重程度及预后的相关性。包括267例CAP患者。获得血液样品。采用酶联免疫吸附试验(ELISA)检测血清IL-2水平。提取人口统计学特征和临床特征。CAP患者血清IL-2随着严重程度评分的增加而逐渐升高。相关分析显示,CAP患者血清IL-2水平与肝、肾功能等生理指标有关。根据逻辑回归分析，血清IL-2与CAP严重程度评分呈正相关。我们还追踪了CAP患者的预后结果。不良预后结果的风险增加，包括机械通气,血管活性剂的使用,入住ICU,死亡,和更长的医院长度，与入院时更高的IL-2水平相关。入院时血清IL-2与CAP患者的严重病情和不良预后呈正相关。提示IL-2可能参与CAP的发生发展。因此,血清IL-2可能是指导临床医生评估CAP严重程度和判断预后的有效生物标志物.
