Abstract：
Traditionally, immunoglobulin (Ig) expression has been attributed solely to B cells/plasma cells with well-documented and accepted regulatory mechanisms governing Ig expression in B cells. Ig transcription is tightly controlled by a series of transcription factors. However, increasing evidence has recently demonstrated that Ig is not only produced by B cell lineages but also by various types of non-B cells (non-B-Ig). Under physiological conditions, non-B-Ig not only exhibits antibody activity but also regulates cellular biological activities (such as promoting cell proliferation, adhesion, and cytoskeleton protein activity). In pathological conditions, non-B-Ig is implicated in the development of various diseases including tumour, kidney disease, and other immune-related disorders. The mechanisms underline Ig gene rearrangement and transcriptional regulation of Ig genes in non-B cells are not fully understood. However, existing evidence suggests that these mechanisms in non-B cells differ from those in B cells. For instance, non-B-Ig gene rearrangement occurs in an RAG-independent manner; and Oct-1 and Oct-4, rather than Oct-2, are required for the transcriptional regulation of non-B derived Igs. In this chapter, we will describe and compare the mechanisms of gene rearrangement and expression regulation between B-Ig and non-B-Ig.
摘要：
传统上,免疫球蛋白(Ig)表达仅归因于B细胞/浆细胞,其具有控制B细胞中Ig表达的充分记录和接受的调节机制。Ig转录受到一系列转录因子的严格控制。然而,最近越来越多的证据表明,Ig不仅由B细胞谱系产生,而且由各种类型的非B细胞(非B-Ig)产生。在生理条件下,non-B-Ig不仅具有抗体活性，而且还调节细胞生物学活性（例如促进细胞增殖，附着力,和细胞骨架蛋白活性）。在病理条件下，非B-Ig与包括肿瘤在内的各种疾病的发展有关，肾病,和其他免疫相关疾病。非B细胞中Ig基因重排和Ig基因转录调控的机制尚不完全清楚。然而,现有证据表明，非B细胞中的这些机制不同于B细胞中的机制。例如,非B-Ig基因重排以不依赖RAG的方式发生；非B衍生Ig的转录调节需要Oct-1和Oct-4，而不是Oct-2。在这一章中,我们将描述和比较B-Ig和非B-Ig之间的基因重排和表达调控机制。
