Abstract：
Although V(D)J recombination and immunoglobulin (Ig) production are traditionally recognised to occur only in B lymphocytes and plasma cells, the expression of Igs in non-lymphoid cells, which we call non B cell-derived Igs (non B Igs), has been documented by growing studies. It has been demonstrated that non B-Igs can be widely expressed in most cell types, including, but not limited to, epithelial cells, cardiomyocytes, hematopoietic stem/progenitor cells, myeloid cells, and cells from immune-privileged sites, such as neurons and spermatogenic cells. In particular, malignant tumour cells express high level of IgG. Moreover, different from B-Igs that mainly localised on the B cell membrane and in the serum and perform immune defence function mainly, non B-Igs have been found to distribute more widely and play critical roles in immune defence, maintaining cell proliferation and survival, and promoting progression. The findings of non B-Igs may provide a wealthier breakthrough point for more therapeutic strategies for a wide range of immune-related diseases.
摘要：
尽管传统上认为V（D）J重组和免疫球蛋白（Ig）产生仅发生在B淋巴细胞和浆细胞中，Ig在非淋巴细胞中的表达，我们称之为非B细胞衍生的Ig（非BIg），已经被越来越多的研究记录了。已经证明，非B-Ig可以在大多数细胞类型中广泛表达，包括,但不限于,上皮细胞，心肌细胞，造血干/祖细胞，骨髓细胞，和免疫特权位点的细胞，如神经元和生精细胞。特别是,恶性肿瘤细胞表达高水平的IgG。此外，与主要定位于B细胞膜和血清中并主要执行免疫防御功能的B-Ig不同，已发现非B-Ig分布更广泛，在免疫防御中起关键作用，维持细胞增殖和存活，促进进步。非B-Ig的发现可能为多种免疫相关疾病的更多治疗策略提供了更富有的突破口。
