Abstract：
Mangiferin is a naturally occurring glucosylxanthone that has shown promising immunomodulatory effects. It is generally isolated from the leaves, peels, bark, and kernels of Mangifera indica Linn. Mangiferin is like a miraculous natural bioactive molecule that has an immunomodulatory function that makes it a potential therapeutic candidate for the treatment of rheumatoid arthritis (RA) and cancer. The anticancer activity of mangiferin acts by blocking NF-κB, as well as regulating the β-catenin, EMT, MMP9, MMP2, LDH, ROS, and NO, and also by the activation of macrophages. It has no cytotoxic effect on grown chondrocytes and lowers matrix metalloproteinase levels. Additionally, it has a potent proapoptotic impact on synoviocytes. The precise molecular mechanism of action of mangiferin on RA and malignancies is still unknown. This comprehensive review elaborates on the immunomodulatory effect of mangiferin and its anticancer and anti-RA activity. This also explained the total synthesis of mangiferin and its in vitro and in vivo screening models.
摘要：
芒果苷是一种天然存在的葡萄糖基黄吨酮，已显示出有希望的免疫调节作用。它通常与叶子隔离，果皮,吠叫,和MangiferaindicaLinn的内核。芒果苷就像一种神奇的天然生物活性分子，具有免疫调节功能，使其成为治疗类风湿性关节炎（RA）和癌症的潜在治疗候选物。芒果苷的抗癌活性通过阻断NF-κB，以及调节β-连环蛋白，EMT,MMP9,MMP2,LDH,ROS,和不,以及巨噬细胞的激活。它对生长的软骨细胞没有细胞毒性作用，并降低基质金属蛋白酶水平。此外,它对滑膜细胞有强烈的促凋亡作用。芒果苷对RA和恶性肿瘤的确切分子作用机制尚不清楚。本文综述了芒果苷的免疫调节作用及其抗癌和抗RA活性。这也解释了芒果苷的全合成及其体外和体内筛选模型。
