Abstract：
The gut microbiota features an abundance of diverse microorganisms and represents an important component of human physiology and metabolic homeostasis, indicating their roles in a wide array of physiological and pathological processes in the host. Maintaining balance in the gut microbiota is critical for normal functionality as microbial dysbiosis can lead to the occurrence and development of diseases through various mechanisms. Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) are non-coding RNAs that perform important regulatory functions for many processes. Furthermore, the gut microbiota and lncRNAs/circRNAs are known to interact in a range of both physiological and pathological activities. In this article, we review existing research relevant to the interaction between the gut microbiota and lncRNAs/circRNAs and investigate the role of their crosstalk in the pathogenesis of different diseases. Studies have shown that, the gut microbiota can target lncRNAs ENO1-IT1, BFAL1, and LINC00152 to regulate colorectal cancer development via various signaling pathways. In addition, the gut microbiota can influence mental diseases and lung tumor metastasis by modulating circRNAs such as circNF1-419, circ_0001239, circHIPK2 and mmu_circ_0000730. These findings provide a theoretical basis for disease prevention and treatment and suggest that gut microbiota-lncRNA/circRNA crosstalk has high clinical value.
摘要：
肠道微生物群以丰富多样的微生物为特征，代表了人体生理和代谢稳态的重要组成部分。表明它们在宿主中广泛的生理和病理过程中的作用。维持肠道微生物群的平衡对于正常功能至关重要，因为微生物菌群失调可以通过各种机制导致疾病的发生和发展。长链非编码RNA(lncRNA)和环状RNA(circRNAs)是对许多过程执行重要调节功能的非编码RNA。此外，已知肠道微生物群和lncRNAs/circRNAs在一系列生理和病理活动中相互作用。在这篇文章中,我们回顾了与肠道微生物群和lncRNAs/circRNAs相互作用相关的现有研究，并探讨了它们在不同疾病发病机制中的作用。研究表明,肠道微生物群可以靶向lncRNAsENO1-IT1、BFAL1和LINC00152，通过各种信号通路调节结直肠癌的发展。此外,肠道菌群可以通过调节circRNAs如cirNF1-419、circ_0001239、cirhIPK2和mmu_circ_0000730来影响精神疾病和肺肿瘤转移。这些发现为疾病的预防和治疗提供了理论依据，并表明肠道微生物群-lncRNA/circRNA串扰具有很高的临床价值。
