PDF(Pubmed)
Abstract：
BACKGROUND: Although observational studies have suggested a correlation between vitiligo and rheumatic diseases, conclusive evidence supporting a causal relationship is still lacking. Therefore, this study aims to explore the potential causal relationship between vitiligo and rheumatic diseases.
METHODS: Using genome-wide association studies, we performed a two-sample Mendelian randomization (MR) analysis. In our analysis, the random-effects inverse variance weighted (IVW) method was predominantly employed, followed by several sensitivity analyses, which include heterogeneity, horizontal pleiotropy, outliers, and \"leave-one-out\" analyses.
RESULTS: The genetically predicted vitiligo was associated with an increased risk of rheumatoid arthritis (RA) (OR, 1.47; 95% confidence interval [CI], 1.29-1.68; p < 0.001), and systemic lupus erythematosus (SLE) (OR, 1.22; 95% CI, 1.06-1.39; p = 0.005). The causal associations were supported by sensitivity analyses. In Sjögren\'s syndrome and ankylosing spondylitis, no causal relationship with vitiligo was found in the study.
CONCLUSIONS: Our MR results support the causal effect that vitiligo leads to a higher risk of RA and SLE. Individuals with vitiligo should be vigilant for the potential development of RA and SLE. Managing and addressing this potential requires regular monitoring.
METHODS: Using genome-wide association studies, we performed a two-sample Mendelian randomization (MR) analysis. In our analysis, the random-effects inverse variance weighted (IVW) method was predominantly employed, followed by several sensitivity analyses, which include heterogeneity, horizontal pleiotropy, outliers, and \"leave-one-out\" analyses.
RESULTS: The genetically predicted vitiligo was associated with an increased risk of rheumatoid arthritis (RA) (OR, 1.47; 95% confidence interval [CI], 1.29-1.68; p < 0.001), and systemic lupus erythematosus (SLE) (OR, 1.22; 95% CI, 1.06-1.39; p = 0.005). The causal associations were supported by sensitivity analyses. In Sjögren\'s syndrome and ankylosing spondylitis, no causal relationship with vitiligo was found in the study.
CONCLUSIONS: Our MR results support the causal effect that vitiligo leads to a higher risk of RA and SLE. Individuals with vitiligo should be vigilant for the potential development of RA and SLE. Managing and addressing this potential requires regular monitoring.
摘要：
背景：尽管观察性研究表明白癜风与风湿性疾病之间存在相关性，仍然缺乏支持因果关系的确凿证据。因此,本研究旨在探讨白癜风与风湿性疾病之间潜在的因果关系。
方法：使用全基因组关联研究，我们进行了双样本孟德尔随机化(MR)分析.在我们的分析中,主要采用随机效应逆方差加权(IVW)方法，随后进行了几次敏感性分析，其中包括异质性，水平多效性，异常值,和“留一法”分析。
结果：基因预测的白癜风与类风湿关节炎（RA）的风险增加有关（OR，1.47；95%置信区间[CI]，1.29-1.68；p<0.001)，和系统性红斑狼疮（SLE）（OR，1.22；95%CI，1.06-1.39；p=0.005）。因果关系得到敏感性分析的支持。在干燥综合征和强直性脊柱炎中，研究中未发现与白癜风的因果关系.
结论：我们的MR结果支持白癜风导致RA和SLE风险较高的因果效应。白癜风患者应警惕RA和SLE的潜在发展。管理和解决这一潜力需要定期监测。
方法：使用全基因组关联研究，我们进行了双样本孟德尔随机化(MR)分析.在我们的分析中,主要采用随机效应逆方差加权(IVW)方法，随后进行了几次敏感性分析，其中包括异质性，水平多效性，异常值,和“留一法”分析。
结果：基因预测的白癜风与类风湿关节炎（RA）的风险增加有关（OR，1.47；95%置信区间[CI]，1.29-1.68；p<0.001)，和系统性红斑狼疮（SLE）（OR，1.22；95%CI，1.06-1.39；p=0.005）。因果关系得到敏感性分析的支持。在干燥综合征和强直性脊柱炎中，研究中未发现与白癜风的因果关系.
结论：我们的MR结果支持白癜风导致RA和SLE风险较高的因果效应。白癜风患者应警惕RA和SLE的潜在发展。管理和解决这一潜力需要定期监测。
