METHODS: This analysis is part of a cross-sectional survey study conducted at the Headache Centre of the Charité-Universitätsmedizin Berlin between August 2020 and March 2023. At the end of their regular medical consultation, patients with migraine filled out (1) the validated RBD Screening Questionnaire (RBDSQ), (2) a questionnaire on REM sleep intrusions and (3) the Depression, Anxiety and Stress Scale 21. The primary endpoint was the percentage of patients with a positive RBD screening. A multivariate analysis was performed to identify characteristics independently associated with features of RBD.
RESULTS: A total of 751 patients (44.1 ± 13.2 years; 87.4% female) with complete RBDSQ were included in this analysis, of which 443 (58.9%) screened positive for RBD. In multivariate analysis, a positive screening for RBD was associated with younger age (odds ratio [OR] 0.9, 95% confidence interval [CI] 0.8-0.9 per 10-year increase; p = 0.005) and with features suggestive of REM sleep intrusions (OR 4.3, 95% CI 1.8-10.4; p = 0.001). Migraine aura remained in the model without reaching statistical significance (OR 1.3, 95% CI 0.9-1.8; p = 0.079).
CONCLUSIONS: Symptoms of RBD are frequent in adults with migraine. Further studies including polysomnography are required to confirm this association, and to explore potential common pathophysiological mechanisms.
方法:该分析是2020年8月至2023年3月在柏林Charité-Universityätsmedizin的头痛中心进行的横断面调查研究的一部分。在他们的常规医疗咨询结束时,偏头痛患者填写(1)验证的RBD筛查问卷(RBDSQ),(2)关于REM睡眠侵入和(3)抑郁症的问卷,焦虑和压力量表21.主要终点是RBD筛查阳性患者的百分比。进行多变量分析以鉴定与RBD特征独立相关的特征。
结果:共有751名患者(44.1±13.2岁;87.4%为女性)具有完整的RBDSQ,其中443例(58.9%)RBD筛查阳性。在多变量分析中,RBD筛查阳性与年龄较小(比值比[OR]0.9,95%置信区间[CI]0.8~0.9每10年增加;p=0.005)相关,且具有提示REM睡眠侵入的特征(OR4.3,95%CI1.8~10.4;p=0.001).模型中仍然存在偏头痛先兆,没有达到统计学意义(OR1.3,95%CI0.9-1.8;p=0.079)。
结论:RBD的症状在患有偏头痛的成年人中常见。需要进一步的研究,包括多导睡眠图,以证实这种关联,并探讨潜在的共同病理生理机制。