Abstract：
OBJECTIVE: Migraine and sleep disorders share a bidirectional relationship, but little is known about the specific association between migraine and rapid eye movement (REM) sleep behaviour disorder (RBD). The aim was to assess the prevalence of RBD and associated clinical characteristics in adults with migraine.
METHODS: This analysis is part of a cross-sectional survey study conducted at the Headache Centre of the Charité-Universitätsmedizin Berlin between August 2020 and March 2023. At the end of their regular medical consultation, patients with migraine filled out (1) the validated RBD Screening Questionnaire (RBDSQ), (2) a questionnaire on REM sleep intrusions and (3) the Depression, Anxiety and Stress Scale 21. The primary endpoint was the percentage of patients with a positive RBD screening. A multivariate analysis was performed to identify characteristics independently associated with features of RBD.
RESULTS: A total of 751 patients (44.1 ± 13.2 years; 87.4% female) with complete RBDSQ were included in this analysis, of which 443 (58.9%) screened positive for RBD. In multivariate analysis, a positive screening for RBD was associated with younger age (odds ratio [OR] 0.9, 95% confidence interval [CI] 0.8-0.9 per 10-year increase; p = 0.005) and with features suggestive of REM sleep intrusions (OR 4.3, 95% CI 1.8-10.4; p = 0.001). Migraine aura remained in the model without reaching statistical significance (OR 1.3, 95% CI 0.9-1.8; p = 0.079).
CONCLUSIONS: Symptoms of RBD are frequent in adults with migraine. Further studies including polysomnography are required to confirm this association, and to explore potential common pathophysiological mechanisms.
METHODS: This analysis is part of a cross-sectional survey study conducted at the Headache Centre of the Charité-Universitätsmedizin Berlin between August 2020 and March 2023. At the end of their regular medical consultation, patients with migraine filled out (1) the validated RBD Screening Questionnaire (RBDSQ), (2) a questionnaire on REM sleep intrusions and (3) the Depression, Anxiety and Stress Scale 21. The primary endpoint was the percentage of patients with a positive RBD screening. A multivariate analysis was performed to identify characteristics independently associated with features of RBD.
RESULTS: A total of 751 patients (44.1 ± 13.2 years; 87.4% female) with complete RBDSQ were included in this analysis, of which 443 (58.9%) screened positive for RBD. In multivariate analysis, a positive screening for RBD was associated with younger age (odds ratio [OR] 0.9, 95% confidence interval [CI] 0.8-0.9 per 10-year increase; p = 0.005) and with features suggestive of REM sleep intrusions (OR 4.3, 95% CI 1.8-10.4; p = 0.001). Migraine aura remained in the model without reaching statistical significance (OR 1.3, 95% CI 0.9-1.8; p = 0.079).
CONCLUSIONS: Symptoms of RBD are frequent in adults with migraine. Further studies including polysomnography are required to confirm this association, and to explore potential common pathophysiological mechanisms.
摘要：
目的：偏头痛和睡眠障碍有双向关系，但对偏头痛与快速眼动（REM）睡眠行为障碍（RBD）之间的具体关联知之甚少。目的是评估成人偏头痛患者RBD的患病率和相关临床特征。
方法：该分析是2020年8月至2023年3月在柏林Charité-Universityätsmedizin的头痛中心进行的横断面调查研究的一部分。在他们的常规医疗咨询结束时，偏头痛患者填写（1）验证的RBD筛查问卷（RBDSQ），(2)关于REM睡眠侵入和(3)抑郁症的问卷，焦虑和压力量表21.主要终点是RBD筛查阳性患者的百分比。进行多变量分析以鉴定与RBD特征独立相关的特征。
结果：共有751名患者（44.1±13.2岁；87.4％为女性）具有完整的RBDSQ，其中443例（58.9%）RBD筛查阳性。在多变量分析中，RBD筛查阳性与年龄较小(比值比[OR]0.9,95%置信区间[CI]0.8~0.9每10年增加;p=0.005)相关,且具有提示REM睡眠侵入的特征(OR4.3,95%CI1.8~10.4;p=0.001).模型中仍然存在偏头痛先兆，没有达到统计学意义（OR1.3，95％CI0.9-1.8；p=0.079）。
结论：RBD的症状在患有偏头痛的成年人中常见。需要进一步的研究，包括多导睡眠图，以证实这种关联，并探讨潜在的共同病理生理机制。
方法：该分析是2020年8月至2023年3月在柏林Charité-Universityätsmedizin的头痛中心进行的横断面调查研究的一部分。在他们的常规医疗咨询结束时，偏头痛患者填写（1）验证的RBD筛查问卷（RBDSQ），(2)关于REM睡眠侵入和(3)抑郁症的问卷，焦虑和压力量表21.主要终点是RBD筛查阳性患者的百分比。进行多变量分析以鉴定与RBD特征独立相关的特征。
结果：共有751名患者（44.1±13.2岁；87.4％为女性）具有完整的RBDSQ，其中443例（58.9%）RBD筛查阳性。在多变量分析中，RBD筛查阳性与年龄较小(比值比[OR]0.9,95%置信区间[CI]0.8~0.9每10年增加;p=0.005)相关,且具有提示REM睡眠侵入的特征(OR4.3,95%CI1.8~10.4;p=0.001).模型中仍然存在偏头痛先兆，没有达到统计学意义（OR1.3，95％CI0.9-1.8；p=0.079）。
结论：RBD的症状在患有偏头痛的成年人中常见。需要进一步的研究，包括多导睡眠图，以证实这种关联，并探讨潜在的共同病理生理机制。
