Abstract：
BACKGROUND: Portal hypertension affects hepatic, splanchnic and portosystemic collateral systems. Although alcohol is a well-known risk factor for liver cirrhosis, it also affects vascular contractility. However, the relevant effects on portal hypertension have not been evaluated in non-alcoholic cirrhosis. This study aimed to investigate the impacts of low-dose alcohol on portal hypertension-related derangements in non-alcoholic cirrhotic rats. Methods: Sprague-Dawley rats received bile duct ligation to induce cirrhosis or sham operation as controls. The chronic or acute effects of low-dose alcohol (2.4 g/kg/day, oral gavage, approximately 1.3 drinks/day in humans) were evaluated. Results: The chronic administration of low-dose alcohol did not precipitate liver fibrosis in the sham or cirrhotic rats, however it significantly increased splanchnic blood inflow (P=0.034) and portosystemic collaterals (P=0.001). Mesenteric angiogenesis and pro-angiogenic proteins were upregulated in the alcohol-treated cirrhotic rats, and poorer collateral vasoresponsiveness to vasoconstrictors (P<0.001) was noted. Consistently, acute alcohol administration reduced splenorenal shunt resistance. Collateral vasoresponsiveness to vasoconstrictors also significantly decreased (P=0.003). Conclusions: In non-alcoholic cirrhosis rats, a single dose of alcohol adversely affected portosystemic collateral vessels due to vasodilatation. Long-term alcohol use precipitated splanchnic hyperdynamic circulation, in which mesenteric angiogenesis played a role. Further studies are warranted to evaluate the benefits of avoiding low-dose alcohol consumption in patients with non-alcoholic cirrhosis.
摘要：
背景：门脉高压影响肝脏，内脏和门体侧支系统。虽然酒精是众所周知的肝硬化的危险因素，它也影响血管收缩性。然而,对门脉高压的相关影响尚未在非酒精性肝硬化中进行评估.本研究旨在探讨低剂量酒精对非酒精性肝硬化大鼠门静脉高压相关紊乱的影响。＆＃160;方法：Sprague-Dawley大鼠接受胆管结扎以诱导肝硬化或假手术作为对照。低剂量酒精的慢性或急性影响（2.4g/kg/天，口服灌胃,评估了人类约1.3杯/天）。＆＃160;结果：长期服用低剂量酒精不会在假手术或肝硬化大鼠中沉淀肝纤维化，然而，它显著增加内脏血液流入(P=0.034)和门体侧支(P=0.001)。肠系膜血管生成和促血管生成蛋白在酒精处理的肝硬化大鼠中上调，对血管收缩剂的侧支血管反应性较差(P<0.001).始终如一，急性酒精给药减少脾肾分流阻力。对血管收缩剂的侧支血管反应性也显著降低(P=0.003)。＆＃160;结论：在非酒精性肝硬化大鼠中，由于血管扩张，单剂量酒精对门体侧支血管产生不利影响。长期饮酒导致内脏高动力循环，其中肠系膜血管生成发挥作用。需要进一步的研究来评估非酒精性肝硬化患者避免低剂量饮酒的益处。
