Abstract：
Zhao, Linggong, Yujie Huang, and Xiaoling Tan. Preexisting hyperuricemia before high-altitude ascent is associated with a slower recovery of estimated glomerular filtration rate following descent. High Alt Med Biol. 00:00-00, 2024. Objectives: Hypoxia at high altitudes results in elevated uric acid (UA) and reduced estimated glomerular filtration rate (eGFR). However, the impact of a prolonged high-altitude sojourn on UA levels and renal function in patients with preexisting hyperuricemia warrants further exploration. The study was to investigate the eGFR and related factors in patients with preexisting hyperuricemia following exposure to high altitude. Methods: The study included 345 participants, who worked at a high altitude for 1 year. Anthropometric and laboratory indices were collected before ascent (i.e., baseline), as well as 20 and 80 days after descent. The participants were categorized into individuals with hyperuricemia (HUA) or normal uric acid (NUA) group based on the presence or absence of hyperuricemia at baseline. Results: No difference in baseline eGFR was observed between the two groups before ascend or on day 20 after descent (p > 0.05). However, on day 80, eGFR of the HUA group was lower compared with the NUA group (p < 0.05). Correlations existed between post-descent eGFR levels and variables, including sampling time, UA levels, total and direct bilirubin, and baseline grouping. Conclusions: After high-altitude exposure, the recovery of eGFR was delayed in participants with preexisting hyperuricemia. Preexisting hyperuricemia and high-altitude hypoxia jointly contribute to renal impairment.
摘要：
赵，灵功,黄玉洁,还有谭小玲。在高海拔上升之前预先存在的高尿酸血症与下降后估计的肾小球滤过率恢复较慢有关。高AltMedBiol。00:00-00,2024.目标：高海拔地区的低氧会导致尿酸（UA）升高和估计的肾小球滤过率（eGFR）降低。然而,在先前存在高尿酸血症的患者中,长时间的高原逗留对UA水平和肾功能的影响值得进一步探讨.该研究旨在调查暴露于高原后先前存在高尿酸血症的患者的eGFR及其相关因素。方法：该研究包括345名参与者，在高海拔地区工作了一年。人体测量和实验室指数在上升前收集(即，基线)，以及下降后20天和80天。根据基线时是否存在高尿酸血症，将参与者分为高尿酸血症（HUA）或正常尿酸（NUA）组。结果：两组在上升前或下降后第20天的基线eGFR无差异（p>0.05）。然而,在第80天，HUA组的eGFR低于NUA组（p<0.05）。下降后eGFR水平与变量之间存在相关性，包括采样时间，UA级别，总胆红素和直接胆红素，和基线分组。结论：在高海拔暴露后，先前存在高尿酸血症的参与者的eGFR恢复延迟.先前存在的高尿酸血症和高原缺氧共同导致肾脏损害。
