PDF(Pubmed)
Abstract：
UNASSIGNED: In recent years, an increasing number of studies have examined the potential efficacy of cognitive training procedures in individuals with normal ageing and mild cognitive impairment (MCI).
UNASSIGNED: The aims of this study were to (i) evaluate the efficacy of the cognitive Virtual Reality Rehabilitation System (VRRS) combined with anodal transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal cortex compared to placebo tDCS stimulation combined with VRRS and (ii) to determine how to prolong the beneficial effects of the treatment. A total of 109 subjects with MCI were assigned to 1 of 5 study groups in a randomized controlled trial design: (a) face-to-face (FTF) VRRS during anodal tDCS followed by cognitive telerehabilitation (TR) (clinic-atDCS-VRRS+Tele@H-VRRS); (b) FTF VRRS during placebo tDCS followed by TR (clinic-ptDCS-VRRS+Tele@H-VRRS); (c) FTF VRRS followed by cognitive TR (clinic-VRRS+Tele@H-VRRS); (d) FTF VRRS followed by at-home unstructured cognitive stimulation (clinic-VRRS+@H-UCS); and (e) FTF cognitive treatment as usual (clinic-TAU).
UNASSIGNED: An improvement in episodic memory was observed after the end of clinic-atDCS-VRRS (p < 0.001). We found no enhancement in episodic memory after clinic-ptDCS-VRRS or after clinic-TAU.Moreover, the combined treatment led to prolonged beneficial effects (clinic-atDCS-VRRS+Tele@H-VRRS vs. clinic-ptDCS-VRRS+Tele@H-VRRS: p = 0.047; clinic-atDCS-VRRS+Tele@H-VRRS vs. clinic-VRRS+Tele@H-VRRS: p = 0.06).
UNASSIGNED: The present study provides preliminary evidence supporting the use of individualized VRRS combined with anodal tDCS and cognitive telerehabilitation for cognitive rehabilitation.
UNASSIGNED: https://clinicaltrials.gov/study/NCT03486704?term=NCT03486704&rank=1, NCT03486704.
UNASSIGNED: The aims of this study were to (i) evaluate the efficacy of the cognitive Virtual Reality Rehabilitation System (VRRS) combined with anodal transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal cortex compared to placebo tDCS stimulation combined with VRRS and (ii) to determine how to prolong the beneficial effects of the treatment. A total of 109 subjects with MCI were assigned to 1 of 5 study groups in a randomized controlled trial design: (a) face-to-face (FTF) VRRS during anodal tDCS followed by cognitive telerehabilitation (TR) (clinic-atDCS-VRRS+Tele@H-VRRS); (b) FTF VRRS during placebo tDCS followed by TR (clinic-ptDCS-VRRS+Tele@H-VRRS); (c) FTF VRRS followed by cognitive TR (clinic-VRRS+Tele@H-VRRS); (d) FTF VRRS followed by at-home unstructured cognitive stimulation (clinic-VRRS+@H-UCS); and (e) FTF cognitive treatment as usual (clinic-TAU).
UNASSIGNED: An improvement in episodic memory was observed after the end of clinic-atDCS-VRRS (p < 0.001). We found no enhancement in episodic memory after clinic-ptDCS-VRRS or after clinic-TAU.Moreover, the combined treatment led to prolonged beneficial effects (clinic-atDCS-VRRS+Tele@H-VRRS vs. clinic-ptDCS-VRRS+Tele@H-VRRS: p = 0.047; clinic-atDCS-VRRS+Tele@H-VRRS vs. clinic-VRRS+Tele@H-VRRS: p = 0.06).
UNASSIGNED: The present study provides preliminary evidence supporting the use of individualized VRRS combined with anodal tDCS and cognitive telerehabilitation for cognitive rehabilitation.
UNASSIGNED: https://clinicaltrials.gov/study/NCT03486704?term=NCT03486704&rank=1, NCT03486704.
摘要：
■近年来，越来越多的研究已经检查了认知训练程序在正常衰老和轻度认知障碍(MCI)患者中的潜在功效.
■这项研究的目的是（i）评估认知虚拟现实康复系统（VRRS）结合经颅直流电刺激（tDCS）应用于左背外侧前额叶皮层的疗效与安慰剂tDCS刺激结合VRRS相比，以及（ii）确定如何延长治疗的有益效果。在随机对照试验设计中，共有109名MCI受试者被分配到5个研究组中的1个：（a）在阳极tDCS期间进行面对面（FTF）VRRS，然后进行认知远程康复（TR）（临床-atDCS-VRRS+Tele@H-VRRS）；（b）安慰剂tDCS期间的FTFVRRS，然后是常规的TR（临床-FTVRS）
■在临床-atDCS-VRRS结束后观察到情景记忆的改善（p<0.001）。我们发现，在临床ptDCS-VRRS或临床TAU后，情景记忆没有增强。此外，联合治疗导致延长的有益效果(临床-atDCS-VRRS+Tele@H-VRRS与临床-ptDCS-VRRS+Tele@H-VRRS：p=0.047；临床-atDCS-VRRS+Tele@H-VRRS与临床VRRS+Tele@H-VRRS：p=0.06）。
■本研究提供了初步证据，支持将个体化VRRS联合节点tDCS和认知远程康复用于认知康复。
■https://clinicaltrials.gov/study/NCT03486704?term=NCT03486704&rank=1,NCT03486704。
■这项研究的目的是（i）评估认知虚拟现实康复系统（VRRS）结合经颅直流电刺激（tDCS）应用于左背外侧前额叶皮层的疗效与安慰剂tDCS刺激结合VRRS相比，以及（ii）确定如何延长治疗的有益效果。在随机对照试验设计中，共有109名MCI受试者被分配到5个研究组中的1个：（a）在阳极tDCS期间进行面对面（FTF）VRRS，然后进行认知远程康复（TR）（临床-atDCS-VRRS+Tele@H-VRRS）；（b）安慰剂tDCS期间的FTFVRRS，然后是常规的TR（临床-FTVRS）
■在临床-atDCS-VRRS结束后观察到情景记忆的改善（p<0.001）。我们发现，在临床ptDCS-VRRS或临床TAU后，情景记忆没有增强。此外，联合治疗导致延长的有益效果(临床-atDCS-VRRS+Tele@H-VRRS与临床-ptDCS-VRRS+Tele@H-VRRS：p=0.047；临床-atDCS-VRRS+Tele@H-VRRS与临床VRRS+Tele@H-VRRS：p=0.06）。
■本研究提供了初步证据，支持将个体化VRRS联合节点tDCS和认知远程康复用于认知康复。
■https://clinicaltrials.gov/study/NCT03486704?term=NCT03486704&rank=1,NCT03486704。
