PDF(Pubmed)
Abstract：
IL-27, a member of the IL-6/IL-12 cytokine superfamily, is primarily secreted by antigen presenting cells, specifically by dendric cells, macrophages and B cells. IL-27 has antiviral activities and modulates both innate and adaptive immune responses against viruses. The role of IL-27 in the setting of viral infections is not well defined and both pro-inflammatory and anti-inflammatory functions have been described. Here, we discuss the latest advancements in the role of IL-27 in several viral infection models of human disease. We highlight important aspects of IL-27 expression regulation, the critical cell sources at different stages of the infection and their impact in cell mediated immunity. Lastly, we discuss the need to better define the antiviral and modulatory (pro-inflammatory vs anti-inflammatory) properties of IL-27 in the context of human chronic viral infections.
摘要：
IL-27，IL-6/IL-12细胞因子超家族的成员，主要由抗原呈递细胞分泌，特别是树枝状细胞，巨噬细胞和B细胞。IL-27具有抗病毒活性并调节针对病毒的先天和适应性免疫应答。IL-27在病毒感染中的作用尚未明确,并且已经描述了促炎和抗炎功能。这里,我们讨论了IL-27在几种人类疾病病毒感染模型中的作用的最新进展。我们强调了IL-27表达调控的重要方面，感染不同阶段的关键细胞来源及其对细胞介导免疫的影响。最后,我们讨论了在人类慢性病毒感染的背景下，需要更好地定义IL-27的抗病毒和调节（促炎与抗炎）特性。
