PDF(Pubmed)
Abstract：
UNASSIGNED: The article studies how Melissa officinalis L. extract and rosmarinic acid (RA) affect lung inflammation, pathology, and oxidative stress in rats with ovalbumin-induced asthma.
UNASSIGNED: Asthma was induced in rats using ovalbumin injection and inhalation. The study assessed lung inflammation, pathological changes, and oxidative stress in control, untreated asthmatic rats and three treatment groups. These groups received M. officinalis extract (50, 100, 200 mg/kg), RA (0.5, 1, 2 mg/kg), or dexamethasone (Dex) 1 mg/kg.
UNASSIGNED: In the sensitized group, white blood cell counts, malondialdehyde, and nitrite levels increased significantly, while thiol levels and the activity of superoxide dismutase and catalase decreased (p<0.001). However, all treatment groups with the extract, RA, and Dex showed a significant reduction in total white blood cells, eosinophils, monocytes, malondialdehyde, and nitrite levels compared to the asthma group (p<0.001 in all groups). Thiol levels and catalase and superoxide dismutase activity were significantly higher in all treated groups with RA and high extract doses (p<0.001). Lung pathological changes were also significantly less severe in the treated groups with dexamethasone, plant extract, and RA compared to the asthma group (p<0.05 to p<0.001).
UNASSIGNED: This study showed that M. officinalis and RA have antioxidant and anti-inflammatory effects in an animal asthma model, suggesting their potential for treating asthma symptoms.
UNASSIGNED: Asthma was induced in rats using ovalbumin injection and inhalation. The study assessed lung inflammation, pathological changes, and oxidative stress in control, untreated asthmatic rats and three treatment groups. These groups received M. officinalis extract (50, 100, 200 mg/kg), RA (0.5, 1, 2 mg/kg), or dexamethasone (Dex) 1 mg/kg.
UNASSIGNED: In the sensitized group, white blood cell counts, malondialdehyde, and nitrite levels increased significantly, while thiol levels and the activity of superoxide dismutase and catalase decreased (p<0.001). However, all treatment groups with the extract, RA, and Dex showed a significant reduction in total white blood cells, eosinophils, monocytes, malondialdehyde, and nitrite levels compared to the asthma group (p<0.001 in all groups). Thiol levels and catalase and superoxide dismutase activity were significantly higher in all treated groups with RA and high extract doses (p<0.001). Lung pathological changes were also significantly less severe in the treated groups with dexamethasone, plant extract, and RA compared to the asthma group (p<0.05 to p<0.001).
UNASSIGNED: This study showed that M. officinalis and RA have antioxidant and anti-inflammatory effects in an animal asthma model, suggesting their potential for treating asthma symptoms.
摘要：
■这篇文章研究了苦瓜提取物和迷迭香酸（RA）如何影响肺部炎症，病理学,卵清蛋白诱导的哮喘大鼠的氧化应激。
■使用卵清蛋白注射和吸入在大鼠中诱发哮喘。这项研究评估了肺部炎症，病理变化,和控制氧化应激，未治疗的哮喘大鼠和三个治疗组。这些组接受M.officinalis提取物（50，100，200mg/kg），RA（0.5、1、2mg/kg），或地塞米松（Dex）1mg/kg。
■在敏化组中，白细胞计数,丙二醛，亚硝酸盐含量显著增加，巯基水平和超氧化物歧化酶和过氧化氢酶活性降低(p<0.001)。然而,所有治疗组的提取物，RA,Dex显示白细胞总数显著减少,嗜酸性粒细胞,单核细胞,丙二醛，和亚硝酸盐水平与哮喘组相比（所有组p<0.001）。在所有RA和高提取物剂量的治疗组中，硫醇水平和过氧化氢酶和超氧化物歧化酶活性均显着较高（p<0.001）。地塞米松治疗组的肺部病理变化也明显较轻，植物提取物,与哮喘组相比，RA（p<0.05至p<0.001）。
■这项研究表明，在动物哮喘模型中，巴草和RA具有抗氧化和抗炎作用，表明它们治疗哮喘症状的潜力。
■使用卵清蛋白注射和吸入在大鼠中诱发哮喘。这项研究评估了肺部炎症，病理变化,和控制氧化应激，未治疗的哮喘大鼠和三个治疗组。这些组接受M.officinalis提取物（50，100，200mg/kg），RA（0.5、1、2mg/kg），或地塞米松（Dex）1mg/kg。
■在敏化组中，白细胞计数,丙二醛，亚硝酸盐含量显著增加，巯基水平和超氧化物歧化酶和过氧化氢酶活性降低(p<0.001)。然而,所有治疗组的提取物，RA,Dex显示白细胞总数显著减少,嗜酸性粒细胞,单核细胞,丙二醛，和亚硝酸盐水平与哮喘组相比（所有组p<0.001）。在所有RA和高提取物剂量的治疗组中，硫醇水平和过氧化氢酶和超氧化物歧化酶活性均显着较高（p<0.001）。地塞米松治疗组的肺部病理变化也明显较轻，植物提取物,与哮喘组相比，RA（p<0.05至p<0.001）。
■这项研究表明，在动物哮喘模型中，巴草和RA具有抗氧化和抗炎作用，表明它们治疗哮喘症状的潜力。
