PDF(Pubmed)
Abstract：
Clinical data on the types of respiratory pathogens which are most frequently engaged in respiratory co-infections of children and adults are lacking. We analyzed 10 years of data on a total of over 15,000 tests for 16 viral and bacterial pathogens detected in clinical samples at the University Hospital of Augsburg, Germany. Co-infection frequencies and their seasonal patterns were examined using a proportional distribution model. Co-infections were detected in 7.3% of samples, with a higher incidence in children and males. The incidence of interbacterial and interviral co-infections was higher than expected, whereas bacterial-viral co-infections were less frequent. H. influenzae, S. pneumoniae, rhinovirus, and respiratory syncytial virus (RSV) were most frequently involved. Most co-infections occurred in winter, but distinct summer peaks were also observed, which occurred even in children, albeit less pronounced than in adults. Seasonality of respiratory (co-)infections decreased with age. Our results suggest to adjust existing testing strategies during high-incidence periods.
摘要：
缺乏有关最常参与儿童和成人呼吸道共感染的呼吸道病原体类型的临床数据。我们分析了在奥格斯堡大学医院的临床样本中检测到的16种病毒和细菌病原体的总计15,000测试的10年数据，德国。使用比例分布模型检查了共感染频率及其季节性模式。在7.3%的样本中检测到共感染,在儿童和男性中发病率较高。细菌间和病毒间共感染的发生率高于预期，而细菌-病毒共感染的发生率较低.流感嗜血杆菌，肺炎链球菌，鼻病毒,呼吸道合胞病毒（RSV）最常见。大多数共感染发生在冬季，但也观察到明显的夏季高峰，甚至发生在儿童身上，尽管不如成年人那么明显。呼吸道（co-）感染的季节性随着年龄的增长而减少。我们的结果表明，在高发时期调整现有的测试策略。
