PDF(Pubmed)
Abstract：
This review systematically examines gender differences in hepatocellular carcinoma (HCC), identifying the influence of sex hormones, genetic variance, and environmental factors on the disease\'s epidemiology and treatment outcomes. Recognizing the liver as a sexually dimorphic organ, we highlight how gender-specific risk factors, such as alcohol consumption and obesity, contribute differently to hepatocarcinogenesis in men and women. We explore molecular mechanisms, including the differential expression of androgen and estrogen receptors, which mediate diverse pathways in tumor biology such as cell proliferation, apoptosis, and DNA repair. Our analysis underscores the critical need for gender-specific research in liver cancer, from molecular studies to clinical trials, to improve diagnostic accuracy and therapeutic effectiveness. By incorporating a gender perspective into all facets of liver cancer research, we advocate for a more precise and personalized approach to cancer treatment that acknowledges gender as a significant factor in both the progression of HCC and its response to treatment. This review aims to foster a deeper understanding of the biological and molecular bases of gender differences in HCC and to promote the development of tailored interventions that enhance outcomes for all patients.
摘要：
这篇综述系统地研究了肝细胞癌（HCC）的性别差异，确定性激素的影响，遗传变异，和环境因素对疾病流行病学和治疗结果的影响。认识到肝脏是性二态器官，我们强调了性别特异性风险因素，比如饮酒和肥胖，在男性和女性中对肝癌发生的贡献不同。我们探索分子机制，包括雄激素和雌激素受体的差异表达，它们介导肿瘤生物学中的多种途径，如细胞增殖，凋亡，DNA修复我们的分析强调了在肝癌中进行性别特异性研究的关键需求，从分子研究到临床试验，以提高诊断准确性和治疗效果。通过将性别观点纳入肝癌研究的各个方面，我们主张采用更精确和个性化的癌症治疗方法,承认性别是HCC进展及其对治疗反应的重要因素.这篇综述旨在加深对HCC性别差异的生物学和分子基础的理解，并促进开发量身定制的干预措施，以提高所有患者的预后。
