PDF(Pubmed)
Abstract：
UNASSIGNED: This study aims to assess the comprehensive and integrated modulatory effects of acupuncture and electroacupuncture on various ovarian dysfunctions.
UNASSIGNED: We systematically searched for articles on animal experiments related to polycystic ovary syndrome (PCOS), premature ovarian failure (POF), premature ovarian insufficiency (POI), and perimenopausal syndrome (PMS) across multiple databases, including PubMed, Web of Science, Cochrane Library, Embase, and four Chinese language databases. The search covered the period from inception to November 2023. We conducted a comparative analysis between the acupuncture group and the model group (untreated) based on eligible literature. Our primary outcomes encompassed serum sex hormones (Luteinizing hormone, Follicle-stimulating hormone, Testosterone, Estradiol, Progesterone, and Anti-Müllerian hormone) and ovarian weight. Dichotomous data were synthesized to establish the relative risk (RR) of notable post-treatment improvement, while continuous data were pooled to determine the standardized mean difference (SMD) in post-treatment scores between the groups. Statistical analyses, including sensitivity analysis, Egger\'s test, and the trim-and-fill method, were executed using Stata 15.0 software.
UNASSIGNED: The meta-analysis encompassed 29 articles involving a total of 623 rats. In comparison to rat models of PCOS, the experimental group exhibited a reduction in serum levels of LH, T and LH/FSH ratio. However, no statistically significant differences were observed in AMH, FSH, E2 levels, and ovarian weight between the two groups. In the ovarian hypoplasia model rats, both acupuncture and electroacupuncture interventions were associated with an increase in E2 levels. However, the levels of LH and FSH did not exhibit a significant difference between the two groups.
UNASSIGNED: Acupuncture or electroacupuncture facilitates the restoration of ovarian function primarily through the modulation of serum sex hormones, exerting regulatory effects across various types of ovarian dysfunction disorders.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022316279.
UNASSIGNED: We systematically searched for articles on animal experiments related to polycystic ovary syndrome (PCOS), premature ovarian failure (POF), premature ovarian insufficiency (POI), and perimenopausal syndrome (PMS) across multiple databases, including PubMed, Web of Science, Cochrane Library, Embase, and four Chinese language databases. The search covered the period from inception to November 2023. We conducted a comparative analysis between the acupuncture group and the model group (untreated) based on eligible literature. Our primary outcomes encompassed serum sex hormones (Luteinizing hormone, Follicle-stimulating hormone, Testosterone, Estradiol, Progesterone, and Anti-Müllerian hormone) and ovarian weight. Dichotomous data were synthesized to establish the relative risk (RR) of notable post-treatment improvement, while continuous data were pooled to determine the standardized mean difference (SMD) in post-treatment scores between the groups. Statistical analyses, including sensitivity analysis, Egger\'s test, and the trim-and-fill method, were executed using Stata 15.0 software.
UNASSIGNED: The meta-analysis encompassed 29 articles involving a total of 623 rats. In comparison to rat models of PCOS, the experimental group exhibited a reduction in serum levels of LH, T and LH/FSH ratio. However, no statistically significant differences were observed in AMH, FSH, E2 levels, and ovarian weight between the two groups. In the ovarian hypoplasia model rats, both acupuncture and electroacupuncture interventions were associated with an increase in E2 levels. However, the levels of LH and FSH did not exhibit a significant difference between the two groups.
UNASSIGNED: Acupuncture or electroacupuncture facilitates the restoration of ovarian function primarily through the modulation of serum sex hormones, exerting regulatory effects across various types of ovarian dysfunction disorders.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022316279.
摘要：
■本研究旨在评估针灸和电针对各种卵巢功能障碍的综合调节作用。
■我们系统地搜索了与多囊卵巢综合征（PCOS）有关的动物实验的文章，卵巢早衰（POF），卵巢早衰(POI),和围绝经期综合征（PMS）跨多个数据库，包括PubMed,WebofScience,科克伦图书馆,Embase,和四个中文数据库。搜索涵盖了从成立到2023年11月的时期。我们根据符合条件的文献对针刺组和模型组（未治疗）进行了比较分析。我们的主要结果包括血清性激素（黄体生成素，卵泡刺激素,睾酮,雌二醇,孕酮,和抗苗勒管激素）和卵巢重量。对二分类数据进行了综合，以建立显着治疗后改善的相对风险（RR），同时汇总连续数据以确定组间治疗后评分的标准化平均差(SMD).统计分析，包括敏感性分析，Egger\'stest,和修剪填充方法，使用Stata15.0软件执行。
■荟萃分析涵盖29篇文章，共涉及623只大鼠。与PCOS的大鼠模型相比，实验组显示血清LH水平降低，T和LH/FSH比值。然而,在AMH中没有观察到统计学上的显着差异，FSH,E2级别,两组之间的卵巢重量。在卵巢发育不全模型大鼠中,针刺和电针干预均与E2水平升高相关.然而,LH和FSH水平在两组之间没有显着差异。
■针灸或电针主要通过调节血清性激素促进卵巢功能的恢复，在各种类型的卵巢功能不全疾病中发挥调节作用。
■https://www.crd.约克。AC.uk/prospro/display_record.php?ID=CRD42022316279。
■我们系统地搜索了与多囊卵巢综合征（PCOS）有关的动物实验的文章，卵巢早衰（POF），卵巢早衰(POI),和围绝经期综合征（PMS）跨多个数据库，包括PubMed,WebofScience,科克伦图书馆,Embase,和四个中文数据库。搜索涵盖了从成立到2023年11月的时期。我们根据符合条件的文献对针刺组和模型组（未治疗）进行了比较分析。我们的主要结果包括血清性激素（黄体生成素，卵泡刺激素,睾酮,雌二醇,孕酮,和抗苗勒管激素）和卵巢重量。对二分类数据进行了综合，以建立显着治疗后改善的相对风险（RR），同时汇总连续数据以确定组间治疗后评分的标准化平均差(SMD).统计分析，包括敏感性分析，Egger\'stest,和修剪填充方法，使用Stata15.0软件执行。
■荟萃分析涵盖29篇文章，共涉及623只大鼠。与PCOS的大鼠模型相比，实验组显示血清LH水平降低，T和LH/FSH比值。然而,在AMH中没有观察到统计学上的显着差异，FSH,E2级别,两组之间的卵巢重量。在卵巢发育不全模型大鼠中,针刺和电针干预均与E2水平升高相关.然而,LH和FSH水平在两组之间没有显着差异。
■针灸或电针主要通过调节血清性激素促进卵巢功能的恢复，在各种类型的卵巢功能不全疾病中发挥调节作用。
■https://www.crd.约克。AC.uk/prospro/display_record.php?ID=CRD42022316279。
