PDF(Pubmed)
Abstract：
UNASSIGNED: No established definition for early-stage knee osteoarthritis (KOA) is available, nor classification criteria. Identifying the characteristics of individuals presenting with early-stage KOA symptoms can enhance diagnosis to prevent progression. This study aimed to describe clinical and structural features of individuals presenting with knee complaints within two years after their first consultation, while exploring differences in the duration of knee complaints.
UNASSIGNED: Baseline data was used from the LITE randomized controlled trial, assessing the effectiveness of a lifestyle intervention for individuals with knee complaints and overweight in primary care. Baseline assessments included questionnaires, clinical assessment, and MRI of the most symptomatic knee. Differences between groups with varying durations of knee complaints (<12, ≥12-<24, ≥24 months) were evaluated.
UNASSIGNED: Participants (N = 218, 65% female, mean age 59 ± 6 years, mean BMI 32 ± 5 kg/m2) had a median knee complaint duration of 14 months, with an average KOOS pain score of 60 ± 17.46% reported their symptoms as unacceptable. Structural MRI-defined KOA was observed in 71% of participants. There were no significant differences in clinical or structural MRI features between different durations of knee complaints.
UNASSIGNED: Within 24 months of initial consultation, over two-thirds of participants displayed MRI-defined structural KOA, and nearly half reported unacceptable symptom states. This study found no association between the duration of knee complaints and symptoms severity or structural KOA presence, underscoring the complexity of identifying stages of KOA among individuals with overweight. Future studies should explore additional features beyond current considerations to facilitate early-stage KOA diagnosis, specifically for individuals with overweight.
UNASSIGNED: Baseline data was used from the LITE randomized controlled trial, assessing the effectiveness of a lifestyle intervention for individuals with knee complaints and overweight in primary care. Baseline assessments included questionnaires, clinical assessment, and MRI of the most symptomatic knee. Differences between groups with varying durations of knee complaints (<12, ≥12-<24, ≥24 months) were evaluated.
UNASSIGNED: Participants (N = 218, 65% female, mean age 59 ± 6 years, mean BMI 32 ± 5 kg/m2) had a median knee complaint duration of 14 months, with an average KOOS pain score of 60 ± 17.46% reported their symptoms as unacceptable. Structural MRI-defined KOA was observed in 71% of participants. There were no significant differences in clinical or structural MRI features between different durations of knee complaints.
UNASSIGNED: Within 24 months of initial consultation, over two-thirds of participants displayed MRI-defined structural KOA, and nearly half reported unacceptable symptom states. This study found no association between the duration of knee complaints and symptoms severity or structural KOA presence, underscoring the complexity of identifying stages of KOA among individuals with overweight. Future studies should explore additional features beyond current considerations to facilitate early-stage KOA diagnosis, specifically for individuals with overweight.
摘要：
■对于早期膝骨性关节炎（KOA）尚无明确的定义，也不是分类标准。识别出现早期KOA症状的个体的特征可以增强诊断以防止进展。这项研究旨在描述在首次咨询后两年内出现膝关节不适的个体的临床和结构特征。同时探索膝关节不适持续时间的差异。
■基线数据来自LITE随机对照试验，评估生活方式干预对初级保健中膝关节主诉和超重患者的有效性.基线评估包括问卷，临床评估,和最有症状的膝盖的MRI。评估了膝关节不适持续时间不同（<12，≥12-<24，≥24个月）的组间差异。
■参与者（N=218，65%为女性，平均年龄59±6岁，平均BMI32±5kg/m2)的膝关节投诉持续时间中位数为14个月，KOOS疼痛的平均评分为60±17.46%，他们的症状是不可接受的。在71％的参与者中观察到MRI定义的结构性KOA。不同膝关节主诉持续时间之间的临床或结构MRI特征没有显着差异。
■在初次咨询后的24个月内，超过三分之二的参与者显示MRI定义的结构性KOA，近一半报告了不可接受的症状状态。这项研究发现，膝关节不适的持续时间与症状严重程度或结构性KOA之间没有关联。强调了在超重个体中识别KOA阶段的复杂性。未来的研究应该探索超出当前考虑的其他特征，以促进早期KOA诊断。特别适合超重的人。
■基线数据来自LITE随机对照试验，评估生活方式干预对初级保健中膝关节主诉和超重患者的有效性.基线评估包括问卷，临床评估,和最有症状的膝盖的MRI。评估了膝关节不适持续时间不同（<12，≥12-<24，≥24个月）的组间差异。
■参与者（N=218，65%为女性，平均年龄59±6岁，平均BMI32±5kg/m2)的膝关节投诉持续时间中位数为14个月，KOOS疼痛的平均评分为60±17.46%，他们的症状是不可接受的。在71％的参与者中观察到MRI定义的结构性KOA。不同膝关节主诉持续时间之间的临床或结构MRI特征没有显着差异。
■在初次咨询后的24个月内，超过三分之二的参与者显示MRI定义的结构性KOA，近一半报告了不可接受的症状状态。这项研究发现，膝关节不适的持续时间与症状严重程度或结构性KOA之间没有关联。强调了在超重个体中识别KOA阶段的复杂性。未来的研究应该探索超出当前考虑的其他特征，以促进早期KOA诊断。特别适合超重的人。
