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Abstract：
The present study aimed to investigate the peculiarities of adaptation of tissue elements of the gastric mucosa during interaction with Helicobacter pylori, as determined by genetic characteristics of the bacterium and the host. Venous blood and biopsy samples of the mucosa of the antrum and body of the stomach from young patients (18 to 25 years old) were examined. The condition of the gastric mucosa was assessed using stained histological preparations. Venous blood was collected from the patients to ascertain the polymorphisms of the IL-lß and IL-IRN genes. The most pronounced changes were observed in the parameters of reparative regeneration of epithelial differentiation during colonization of the gastric mucosa by H. pylori strains carrying the CagA(+) and BabA2(+) genes. These included an increase in proliferation and apoptosis rates and alterations in epithelial differentiation markers characterized by elevated production of Shh and MUC5AC, as well as a reduction in the production of the protective mucin MUC6 by isthmus gland cells. The presence of the vacAs1 and vacAs2 genes of H. pylori results in a high level of apoptosis in epithelial cells without accelerating proliferation. It was found that after eradication, patients with preserved cellular infiltrates in their gastric mucosa plates were carriers of mainly the IL-1ß*T/IL-1RN*2R haplotypes after 12 months.
摘要：
本研究旨在研究与幽门螺杆菌相互作用时胃粘膜组织成分的适应特性，取决于细菌和宿主的遗传特征。检查了年轻患者（18至25岁）的胃窦和胃体粘膜的静脉血和活检样本。使用染色的组织学制剂评估胃粘膜的状况。从患者收集静脉血以确定IL-1β和IL-IRN基因的多态性。携带CagA（）和BabA2（）基因的幽门螺杆菌菌株在胃粘膜定植过程中，上皮分化的修复性再生参数观察到了最明显的变化。这些包括增殖和凋亡率的增加以及以Shh和MUC5AC产生升高为特征的上皮分化标志物的改变。以及峡部腺细胞产生保护性粘蛋白MUC6的减少。幽门螺杆菌的vacAs1和vacAs2基因的存在导致上皮细胞中高水平的凋亡而不加速增殖。发现根除后，胃粘膜板细胞浸润保留的患者在12个月后主要是IL-1β*T/IL-1RN*2R单倍型的携带者.
