Abstract：
BACKGROUND: Mean corpuscular hemoglobin concentration (MCHC) is one of the parameters detected by blood cell analyzers, often used together with mean corpuscular volume (MCV) and mean corpuscular hemoglobin content (MCH) as diagnostic indicators for anemia classification. It has important clinical value in early detection of the cause of anemia and the underlying etiology of anemia. Therefore, the accuracy of MCHC results is of great significance for the diagnosis and treatment of diseases.
METHODS: We reported two cases of false elevation of MCHC. Considering the possibility of cold agglutination and lipid blood interference detection, we used 37℃ water bath and plasma exchange to correct for interference on the sample.
RESULTS: After correcting the interference, MCHC returned to normal, consistent with the patient\'s disease status. Therefore, the two cases of abnormal elevation of MCHC are considered to be pseudo elevation caused by interference.
CONCLUSIONS: For specimens with abnormally elevated MCHC levels, experimenters should first analyze possible interfering factors and choose effective methods to correct different interferences, providing accurate testing reports for doctors and patients.
METHODS: We reported two cases of false elevation of MCHC. Considering the possibility of cold agglutination and lipid blood interference detection, we used 37℃ water bath and plasma exchange to correct for interference on the sample.
RESULTS: After correcting the interference, MCHC returned to normal, consistent with the patient\'s disease status. Therefore, the two cases of abnormal elevation of MCHC are considered to be pseudo elevation caused by interference.
CONCLUSIONS: For specimens with abnormally elevated MCHC levels, experimenters should first analyze possible interfering factors and choose effective methods to correct different interferences, providing accurate testing reports for doctors and patients.
摘要：
背景：平均红细胞血红蛋白浓度（MCHC）是血细胞分析仪检测到的参数之一，通常与平均红细胞体积（MCV）和平均红细胞血红蛋白含量（MCH）一起用作贫血分类的诊断指标。它对早期发现贫血的病因和贫血的潜在病因具有重要的临床价值。因此,MCHC结果的准确性对疾病的诊断和治疗具有重要意义。
方法：我们报告了2例MCHC假性升高。考虑到冷凝集和血脂干扰检测的可能性，我们使用37℃水浴和血浆置换来校正对样品的干扰。
结果：校正干扰后，MCHC恢复正常,与患者的疾病状态一致。因此,2例MCHC异常抬高均为干扰引起的伪抬高。
结论：对于MCHC水平异常升高的标本，实验者应首先分析可能的干扰因素，并选择有效的方法来纠正不同的干扰，为医生和患者提供准确的检测报告。
方法：我们报告了2例MCHC假性升高。考虑到冷凝集和血脂干扰检测的可能性，我们使用37℃水浴和血浆置换来校正对样品的干扰。
结果：校正干扰后，MCHC恢复正常,与患者的疾病状态一致。因此,2例MCHC异常抬高均为干扰引起的伪抬高。
结论：对于MCHC水平异常升高的标本，实验者应首先分析可能的干扰因素，并选择有效的方法来纠正不同的干扰，为医生和患者提供准确的检测报告。
