Abstract：
BACKGROUND: The comprehensive impact of prolonged home-based resistance training on individuals grappling with chronic kidney disease (CKD) have yet to be fully elucidated. This study aimed to explore the outcomes of varying exercise durations on physical performance, nutritional status, and kidney function within this specific population, encompassing patients undergoing dialysis and those affected by severe sarcopenia.
METHODS: This was a 1-year observational double cohort study following a 52-week longitudinal design, we enrolled 101 adult CKD outpatients. These participants were divided into two groups: the continuous group, comprising individuals who consistently exercised for over 6 months, and the interrupted group, which included those who did not sustain regular exercise for the same duration. The exercise regimen involved resistance exercises conducted at least 3 to 5 days per week, involving activities like lifting dumbbells and executing weighted wall squats. Physical activity assessments and biochemical blood tests were conducted at weeks 0, 4, 16, 28, 40, and 52 for all participants.
RESULTS: The continuous exercise group exhibited better handgrip strength and sit-to-stand movement compared to the interrupted group. Their estimated glomerular filtration rate stayed steady while the interrupted group was declined. Additionally, those who exercised consistently had better metabolism: higher carbon dioxide levels, increased albumin, better nutritional scores, and lower levels of blood urea nitrogen, creatinine, fasting blood glucose, and body weight. Subsequent adjustments for potential confounding factors continued to show improved physical performance and kidney function over time.
CONCLUSIONS: Our findings indicate the advantageous impact of extended resistance exercise training on overall health of CKD patients, even those on dialysis or with severe sarcopenia. Dedication to this exercise routine could improve kidney function, metabolism, and physical abilities in these patients.
METHODS: This was a 1-year observational double cohort study following a 52-week longitudinal design, we enrolled 101 adult CKD outpatients. These participants were divided into two groups: the continuous group, comprising individuals who consistently exercised for over 6 months, and the interrupted group, which included those who did not sustain regular exercise for the same duration. The exercise regimen involved resistance exercises conducted at least 3 to 5 days per week, involving activities like lifting dumbbells and executing weighted wall squats. Physical activity assessments and biochemical blood tests were conducted at weeks 0, 4, 16, 28, 40, and 52 for all participants.
RESULTS: The continuous exercise group exhibited better handgrip strength and sit-to-stand movement compared to the interrupted group. Their estimated glomerular filtration rate stayed steady while the interrupted group was declined. Additionally, those who exercised consistently had better metabolism: higher carbon dioxide levels, increased albumin, better nutritional scores, and lower levels of blood urea nitrogen, creatinine, fasting blood glucose, and body weight. Subsequent adjustments for potential confounding factors continued to show improved physical performance and kidney function over time.
CONCLUSIONS: Our findings indicate the advantageous impact of extended resistance exercise training on overall health of CKD patients, even those on dialysis or with severe sarcopenia. Dedication to this exercise routine could improve kidney function, metabolism, and physical abilities in these patients.
摘要：
背景：长期家庭抗阻训练对慢性肾脏病（CKD）患者的综合影响尚未完全阐明。本研究旨在探讨不同运动持续时间对身体表现的影响。营养状况,和这个特定人群的肾功能，包括接受透析的患者和严重肌少症患者。
方法：这是一项为期1年的双队列观察研究，经过52周的纵向设计，我们纳入101名成人CKD门诊患者.这些参与者被分为两组：连续组，包括持续锻炼超过6个月的个人，和被打断的小组，其中包括那些没有在相同持续时间内进行定期锻炼的人。锻炼方案包括每周至少进行3至5天的阻力锻炼，涉及举起哑铃和执行加权深蹲等活动。所有参与者在第0、4、16、28、40和52周进行身体活动评估和生化血液测试。
结果：与中断组相比，连续运动组表现出更好的握力和坐到站运动。他们估计的肾小球滤过率保持稳定，而中断组下降。此外,那些持续锻炼的人有更好的新陈代谢:更高的二氧化碳水平，白蛋白增加，更好的营养评分，和较低的血尿素氮水平，肌酐,空腹血糖,和体重。随后对潜在混杂因素的调整继续显示出随着时间的推移改善的身体表现和肾功能。
结论：我们的研究结果表明，延长抗阻运动训练对CKD患者的整体健康具有有利的影响，即使是那些透析或严重的肌肉减少症。坚持这种锻炼方式可以改善肾功能，新陈代谢，这些患者的身体能力。
方法：这是一项为期1年的双队列观察研究，经过52周的纵向设计，我们纳入101名成人CKD门诊患者.这些参与者被分为两组：连续组，包括持续锻炼超过6个月的个人，和被打断的小组，其中包括那些没有在相同持续时间内进行定期锻炼的人。锻炼方案包括每周至少进行3至5天的阻力锻炼，涉及举起哑铃和执行加权深蹲等活动。所有参与者在第0、4、16、28、40和52周进行身体活动评估和生化血液测试。
结果：与中断组相比，连续运动组表现出更好的握力和坐到站运动。他们估计的肾小球滤过率保持稳定，而中断组下降。此外,那些持续锻炼的人有更好的新陈代谢:更高的二氧化碳水平，白蛋白增加，更好的营养评分，和较低的血尿素氮水平，肌酐,空腹血糖,和体重。随后对潜在混杂因素的调整继续显示出随着时间的推移改善的身体表现和肾功能。
结论：我们的研究结果表明，延长抗阻运动训练对CKD患者的整体健康具有有利的影响，即使是那些透析或严重的肌肉减少症。坚持这种锻炼方式可以改善肾功能，新陈代谢，这些患者的身体能力。
