PDF(Pubmed)
Abstract：
OBJECTIVE: To evaluate the available evidence regarding the quality of life (QoL) in patients with acromegaly, by synthesizing the psychosocial factors of QoL, QoL measures, and complementary interventions targeting QoL.
METHODS: A scoping review was conducted using the PRISMA-ScR guideline. We searched six English databases (PubMed, Embase, CINAHL, Scopus, Web of Science, and the Cochrane Library) from the inception to August 21, 2023. We included observational studies involving psychosocial factors and complementary interventions targeting QoL (concept) in patients with acromegaly (population) in any setting (context). The design characteristics, psychosocial factors, measures, details of interventions, and outcomes of included studies were described in detail.
RESULTS: Twenty-one studies were identified, including sixteen cross-sectional studies and five interventional studies. Ten categories of psychosocial factors that are associated with QoL in acromegaly. Depression and anxiety were the most frequent psychosocial factors. Seven different validated QoL measures were used. AcroQoL was the most common measure. Two categories of complementary interventions targeting QoL were identified including psychological and exercise interventions.
CONCLUSIONS: Our scoping review provides a reasonably clear picture of the current research status of QoL in acromegaly. However, this review also highlights the need to deepen understanding of QoL and psychosocial factors in the future, as well as conduct longitudinal research and qualitative research to clarify the changing trends of psychosocial factors and specific experiences of patients. Further, more potential clinical complementary interventions are needed to improve QoL for patients with acromegaly.
METHODS: A scoping review was conducted using the PRISMA-ScR guideline. We searched six English databases (PubMed, Embase, CINAHL, Scopus, Web of Science, and the Cochrane Library) from the inception to August 21, 2023. We included observational studies involving psychosocial factors and complementary interventions targeting QoL (concept) in patients with acromegaly (population) in any setting (context). The design characteristics, psychosocial factors, measures, details of interventions, and outcomes of included studies were described in detail.
RESULTS: Twenty-one studies were identified, including sixteen cross-sectional studies and five interventional studies. Ten categories of psychosocial factors that are associated with QoL in acromegaly. Depression and anxiety were the most frequent psychosocial factors. Seven different validated QoL measures were used. AcroQoL was the most common measure. Two categories of complementary interventions targeting QoL were identified including psychological and exercise interventions.
CONCLUSIONS: Our scoping review provides a reasonably clear picture of the current research status of QoL in acromegaly. However, this review also highlights the need to deepen understanding of QoL and psychosocial factors in the future, as well as conduct longitudinal research and qualitative research to clarify the changing trends of psychosocial factors and specific experiences of patients. Further, more potential clinical complementary interventions are needed to improve QoL for patients with acromegaly.
摘要：
目的：评估有关肢端肥大症患者生活质量（QoL）的现有证据，通过综合生活质量的社会心理因素，QoL措施，以及针对QoL的补充干预措施。
方法：使用PRISMA-ScR指南进行范围审查。我们搜索了六个英语数据库(PubMed，Embase,CINAHL,Scopus,WebofScience,和Cochrane图书馆）从成立到2023年8月21日。我们纳入了涉及心理社会因素和针对QoL（概念）的补充干预措施的观察性研究，这些措施适用于任何环境（背景）中的肢端肥大症患者（人群）。设计特点，社会心理因素,措施，干预措施的细节，并详细描述了纳入研究的结果.
结果：确定了21项研究，包括16项横断面研究和5项介入研究。与肢端肥大症QoL相关的十类心理社会因素。抑郁和焦虑是最常见的心理社会因素。使用了七种不同的经过验证的QoL度量。AcroQoL是最常见的测量。确定了针对QoL的两类补充干预措施，包括心理干预和运动干预。
结论：我们的范围审查提供了一个相当清晰的关于QoL在肢端肥大症中的研究现状。然而,这篇综述还强调了未来需要加深对QoL和社会心理因素的理解，以及进行纵向研究和定性研究，以阐明心理社会因素的变化趋势和患者的具体经历。Further,对于肢端肥大症患者,需要更多潜在的临床补充干预措施来改善QoL.
方法：使用PRISMA-ScR指南进行范围审查。我们搜索了六个英语数据库(PubMed，Embase,CINAHL,Scopus,WebofScience,和Cochrane图书馆）从成立到2023年8月21日。我们纳入了涉及心理社会因素和针对QoL（概念）的补充干预措施的观察性研究，这些措施适用于任何环境（背景）中的肢端肥大症患者（人群）。设计特点，社会心理因素,措施，干预措施的细节，并详细描述了纳入研究的结果.
结果：确定了21项研究，包括16项横断面研究和5项介入研究。与肢端肥大症QoL相关的十类心理社会因素。抑郁和焦虑是最常见的心理社会因素。使用了七种不同的经过验证的QoL度量。AcroQoL是最常见的测量。确定了针对QoL的两类补充干预措施，包括心理干预和运动干预。
结论：我们的范围审查提供了一个相当清晰的关于QoL在肢端肥大症中的研究现状。然而,这篇综述还强调了未来需要加深对QoL和社会心理因素的理解，以及进行纵向研究和定性研究，以阐明心理社会因素的变化趋势和患者的具体经历。Further,对于肢端肥大症患者,需要更多潜在的临床补充干预措施来改善QoL.
