PDF(Pubmed)
Abstract：
It is unclear whether polycystic ovary syndrome (PCOS) is an independent risk factor for adverse birth outcomes in the offspring of affected women. Here, we investigate the association of PCOS with birth outcomes in the offspring of women with PCOS overall and by potential confounders. This systematic review and meta-analysis included 73 studies and 92,881 offspring of women with and without PCOS from inception until 13th July 2022. We report that mothers with PCOS are younger and have higher body mass index (BMI) around conception and have greater gestational weight gain. The odds of preterm birth, fetal growth restriction and low birth weight are higher and mean birthweight is lower in PCOS of which a lower mean birthweight and a higher small for gestational age are probably independent of BMI. This work informed the recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome, emphasizing that PCOS status should be captured at pregnancy to identify risk and improve birth outcomes in the offspring.
摘要：
目前尚不清楚多囊卵巢综合征（PCOS）是否是患病妇女后代不良分娩结局的独立危险因素。这里,我们调查了PCOS患者后代中PCOS与出生结局的总体关系以及潜在的混杂因素.这项系统评价和荟萃分析包括从开始到2022年7月13日，有和没有PCOS的妇女的73项研究和92,881个后代。我们报告说，患有PCOS的母亲更年轻，怀孕前后的体重指数（BMI）更高，并且妊娠期体重增加更大。早产的几率,在PCOS中,胎儿生长受限和低出生体重较高,平均出生体重较低,而平均出生体重较低可能与BMI无关.这项工作为2023年国际循证指南的多囊卵巢综合征评估和管理提供了建议。强调应在怀孕时记录PCOS状态，以确定风险并改善后代的出生结局。
