PDF(Pubmed)
Abstract：
Screening for polycystic ovary syndrome (PCOS) in antenatal care is inadequate, largely owing to the lack of clarity around whether PCOS is an independent risk factor for pregnancy complications. This systematic review and meta-analysis include 104 studies and 106,690 pregnancies in women with and without PCOS from inception until 13th July 2022. We report that women with PCOS are younger and have higher body mass index (BMI) around conception and have greater gestational weight gain. The odds of miscarriage, gestational diabetes mellitus, gestational hypertension, pre-eclampsia and cesarean section are higher in women with PCOS. The increased odds of adverse outcomes in PCOS remain significant when age and BMI are matched and when analyses are restricted to high-quality studies. This work informed the recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome, emphasizing that PCOS status should be captured in all women who are planning to, or have recently become pregnant to facilitate prevention of adverse outcomes and improve pregnancy outcomes.
摘要：
在产前护理中筛查多囊卵巢综合征（PCOS）是不够的，主要是由于对PCOS是否是妊娠并发症的独立危险因素尚不清楚。这项系统评价和荟萃分析包括从开始到2022年7月13日，有和没有PCOS的妇女的104项研究和106,690例怀孕。我们报告说，患有PCOS的女性更年轻，怀孕前后的体重指数（BMI）更高，并且妊娠期体重增加更大。流产的几率,妊娠期糖尿病,妊娠期高血压,PCOS患者先兆子痫和剖宫产率较高.当年龄和BMI匹配并且分析仅限于高质量研究时，PCOS不良结局的几率增加仍然显着。这项工作为2023年国际循证指南的多囊卵巢综合征评估和管理提供了建议。强调PCOS的地位应该在所有计划的妇女中得到体现，或最近怀孕，以促进预防不良结局和改善妊娠结局。
