PDF(Pubmed)
Abstract：
Autoimmune diseases commonly affect various systems, but their etiology and pathogenesis remain unclear. Currently, increasing research has highlighted the role of ferroptosis in immune regulation, with immune cells being a crucial component of the body\'s immune system. This review provides an overview and discusses the relationship between ferroptosis, programmed cell death in immune cells, and autoimmune diseases. Additionally, it summarizes the role of various key targets of ferroptosis, such as GPX4 and TFR, in immune cell immune responses. Furthermore, the release of multiple molecules, including damage-associated molecular patterns (DAMPs), following cell death by ferroptosis, is examined, as these molecules further influence the differentiation and function of immune cells, thereby affecting the occurrence and progression of autoimmune diseases. Moreover, immune cells secrete immune factors or their metabolites, which also impact the occurrence of ferroptosis in target organs and tissues involved in autoimmune diseases. Iron chelators, chloroquine and its derivatives, antioxidants, chloroquine derivatives, and calreticulin have been demonstrated to be effective in animal studies for certain autoimmune diseases, exerting anti-inflammatory and immunomodulatory effects. Finally, a brief summary and future perspectives on the research of autoimmune diseases are provided, aiming to guide disease treatment strategies.
摘要：
自身免疫性疾病通常影响各个系统，但其病因和发病机制尚不清楚。目前,越来越多的研究强调了铁死亡在免疫调节中的作用，免疫细胞是人体免疫系统的重要组成部分。这篇综述提供了概述，并讨论了铁性凋亡之间的关系，免疫细胞中的程序性细胞死亡，和自身免疫性疾病。此外,它总结了铁性凋亡的各种关键靶标的作用，例如GPX4和TFR，在免疫细胞免疫反应中。此外，释放多种分子，包括损伤相关分子模式(DAMP)，在通过铁凋亡导致细胞死亡之后，被检查，这些分子进一步影响免疫细胞的分化和功能，从而影响自身免疫性疾病的发生和进展。此外，免疫细胞分泌免疫因子或其代谢产物,这也影响了与自身免疫性疾病有关的靶器官和组织中铁性凋亡的发生。铁螯合剂,氯喹及其衍生物，抗氧化剂,氯喹衍生物，钙网蛋白已被证明在某些自身免疫性疾病的动物研究中有效，发挥抗炎和免疫调节作用。最后,对自身免疫性疾病的研究进行了简要总结和未来展望，旨在指导疾病治疗策略。
