Abstract：
Immune dysregulation in autoimmune diseases (ADs) is a risk factor for the development of Non-Hodgkin\'s lymphoma (NHL). However, the underlying mechanisms are not well understood. Hence, this retrospective study aims to describe the clinical and demographic factors that increase the risk of NHL development in patients with ADs. Our study utilised data from National Inpatient Sample (NIS) for the duration of 2016-2020 on all adult patients aged > 18 years who had NHL. We divided them into two cohorts: one with underlying ADs and one without underlying ADs. We then compared the adjusted odds ratios (aOR) of various risk factors. It was found that 0.9% of autoimmune cases had NHL, while 0.7% of non-autoimmune cases had NHL. Among those with autoimmune conditions, various factors influenced the presence of lymphoma, such as personal history of chemotherapy or radiation, family history of lymphoid malignancy, HIV infection, advanced age of 60-69 years, Asian and Pacific Islander ethnicity and viral hepatitis. The increased risk of NHL with autoimmune conditions is well established. Studies have also shown that these patients can overall have a poor prognosis from their NHL when compared to patients without autoimmune diseases. However, there is limited literature regarding the interplay of traditional NHL risk factors with underlying autoimmunity. Hence, our study sheds light on the lesser studied risk factors, such as patient characteristics and comorbidities.
摘要：
自身免疫性疾病（ADs）中的免疫失调是非霍奇金淋巴瘤（NHL）发展的危险因素。然而,潜在的机制还没有得到很好的理解。因此，这项回顾性研究旨在描述增加ADs患者NHL发展风险的临床和人口统计学因素.我们的研究利用了2016-2020年期间所有年龄>18岁患有NHL的成年患者的国家住院患者样本（NIS）的数据。我们将它们分为两个队列：一个有基础AD，一个没有基础AD。然后，我们比较了各种风险因素的调整后优势比(aOR)。发现0.9％的自身免疫性病例患有NHL，而0.7%的非自身免疫性病例患有NHL。在那些患有自身免疫性疾病的人中，各种因素影响淋巴瘤的存在，如个人化疗或放疗史，淋巴恶性肿瘤家族史，HIV感染,60-69岁高龄,亚洲和太平洋岛民种族和病毒性肝炎。具有自身免疫病症的NHL的增加的风险是充分确定的。研究还表明，与没有自身免疫性疾病的患者相比，这些患者的NHL总体预后较差。然而,关于传统NHL危险因素与潜在自身免疫相互作用的文献有限.因此，我们的研究揭示了较少研究的风险因素，如患者特征和合并症。
