Abstract：
OBJECTIVE: Soluble transferrin receptor (sTfR) is a marker of both erythropoiesis and iron status and is considered useful for detecting iron deficiency, especially in inflammatory conditions, but reference intervals covering the entire pediatric age spectrum are lacking.
METHODS: We studied 1,064 (48.5 % female) healthy children of the entire pediatric age spectrum to determine reference values and percentiles for sTfR and the ratio of sTfR to log-ferritin (sTfR-F index) using a standard immunoturbidimetric assay.
RESULTS: Soluble TfR levels were highly age-specific, with a peak in infancy and a decline in adulthood, whereas the sTfR-F index was a rather constant parameter. There were positive linear relationships for sTfR with hemoglobin (Hb) (p=0.008) and transferrin (females p<0.001; males p=0.003). A negative association was observed between sTfR and ferritin in females (p<0.0001) and for transferrin saturation and mean corpuscular volume (MCV) in both sexes (both p<0.0001). We found a positive relationship between sTfR and body height, body mass index (BMI) and inflammatory markers (CrP p<0.0001; WBC p=0.0172), while sTfR-F index was not affected by inflammation.
CONCLUSIONS: Soluble TfR values appear to reflect the activity of infant erythropoiesis and to be modulated by inflammation and iron deficiency even in a healthy cohort.
METHODS: We studied 1,064 (48.5 % female) healthy children of the entire pediatric age spectrum to determine reference values and percentiles for sTfR and the ratio of sTfR to log-ferritin (sTfR-F index) using a standard immunoturbidimetric assay.
RESULTS: Soluble TfR levels were highly age-specific, with a peak in infancy and a decline in adulthood, whereas the sTfR-F index was a rather constant parameter. There were positive linear relationships for sTfR with hemoglobin (Hb) (p=0.008) and transferrin (females p<0.001; males p=0.003). A negative association was observed between sTfR and ferritin in females (p<0.0001) and for transferrin saturation and mean corpuscular volume (MCV) in both sexes (both p<0.0001). We found a positive relationship between sTfR and body height, body mass index (BMI) and inflammatory markers (CrP p<0.0001; WBC p=0.0172), while sTfR-F index was not affected by inflammation.
CONCLUSIONS: Soluble TfR values appear to reflect the activity of infant erythropoiesis and to be modulated by inflammation and iron deficiency even in a healthy cohort.
摘要：
目的：可溶性转铁蛋白受体（sTfR）是红细胞生成和铁状态的标志物，被认为可用于检测缺铁，尤其是在炎症条件下，但缺乏覆盖整个儿科年龄段的参考区间。
方法：我们研究了整个儿科年龄段的1,064名（48.5％女性）健康儿童，以确定sTfR的参考值和百分位数以及sTfR与对数铁蛋白的比率（sTfR-F指数）使用标准免疫比浊法测定。
结果：可溶性TfR水平高度因年龄而异，婴儿期达到顶峰，成年期下降，而sTfR-F指数是一个相当恒定的参数。sTfR与血红蛋白（Hb）（p=0.008）和转铁蛋白（女性p<0.001；男性p=0.003）呈正线性关系。在女性中，sTfR和铁蛋白（p<0.0001）与转铁蛋白饱和度和平均红细胞体积（MCV）之间呈负相关（均p<0.0001）。我们发现sTfR和身高之间存在正相关关系,体重指数（BMI）和炎症标志物（CrPp<0.0001;WBCp=0.0172），而sTfR-F指数不受炎症的影响。
结论：即使在健康队列中，可溶性TfR值似乎也反映了婴儿红细胞生成的活性，并受到炎症和铁缺乏的调节。
方法：我们研究了整个儿科年龄段的1,064名（48.5％女性）健康儿童，以确定sTfR的参考值和百分位数以及sTfR与对数铁蛋白的比率（sTfR-F指数）使用标准免疫比浊法测定。
结果：可溶性TfR水平高度因年龄而异，婴儿期达到顶峰，成年期下降，而sTfR-F指数是一个相当恒定的参数。sTfR与血红蛋白（Hb）（p=0.008）和转铁蛋白（女性p<0.001；男性p=0.003）呈正线性关系。在女性中，sTfR和铁蛋白（p<0.0001）与转铁蛋白饱和度和平均红细胞体积（MCV）之间呈负相关（均p<0.0001）。我们发现sTfR和身高之间存在正相关关系,体重指数（BMI）和炎症标志物（CrPp<0.0001;WBCp=0.0172），而sTfR-F指数不受炎症的影响。
结论：即使在健康队列中，可溶性TfR值似乎也反映了婴儿红细胞生成的活性，并受到炎症和铁缺乏的调节。
