Abstract：
Marine microalgae serve as an aquaculture bait. To enhance algal cell growth and breeding profits, high-intensity light conditions are standard for cultivating bait microalgae, potentially altering microalgal metabolite production. This research revealed that Thalassiosira pseudonana, when subjected to high-intensity light conditions, accumulated significant quantities of retinal (RAL) that transferred through the food chain and transformed into all-trans retinoic acid (atRA) in marine medaka. The study further explored the toxic effects on individual fish and specific tissues, as well as the mechanisms behind this toxicity. The accumulation of atRA in the liver, intestine, and spinal column resulted in structural damage and tissue inflammation, as well as oxidative stress. It also down-regulated the gene transcription levels of key pathways involved in immune function and growth. Furthermore, it disrupted the homeostasis of the intestinal microbial communities. The implications for wildlife and human health, which are influenced by the regulation of microalgal metabolite accumulation and their transfer via the food chain, require further investigation and could hold broader significance.
摘要：
海洋微藻用作水产养殖诱饵。为了提高藻类细胞的生长和繁殖利润，高强度光照条件是培养诱饵微藻的标准，可能改变微藻代谢产物的生产。这项研究表明，thalassiosirapseudonana，当受到高强度光线条件时，积累了大量的视网膜（RAL），这些视网膜通过食物链转移并在海洋中转化为全反式维甲酸（atRA）。该研究进一步探索了对个体鱼类和特定组织的毒性作用，以及这种毒性背后的机制。atRA在肝脏中的积累，肠,和脊柱导致结构损伤和组织炎症，以及氧化应激。它还下调涉及免疫功能和生长的关键途径的基因转录水平。此外，它破坏了肠道微生物群落的稳态。对野生动物和人类健康的影响，它们受到微藻代谢产物积累及其通过食物链转移的调节的影响，需要进一步调查，可能具有更广泛的意义。
