Abstract：
Osteoporosis (OP) is a systemic skeletal disease that is characterized by low bone mass and increased fracture risk. This article explores the potential of probiotics as an adjunctive approach for the prevention and management of OP. It has been well established that the gut microbiota (GM), a complex community of microbes, plays an important role in bone health. The gut dysbiosis is linked with a higher risk of OP. However, the consumption of probiotics in adequate amounts restores gut health thus improving bone health. Probiotics may influence bone metabolism through enhanced calcium absorption, reduced inflammation, and increased bone formation. The animal and human studies demonstrate the positive effects of probiotics on bone health parameters like reduced osteoclastogenesis, bone resorption markers, osteoblast, osteocyte apoptosis, and increased bone mineral density and expression of osteoprotegerin. The current evidence suggests that probiotics can be used as an adjunctive approach along with the existing therapies for the prevention and management of OP.
摘要：
骨质疏松（OP）是一种全身性骨骼疾病，其特征是骨量低和骨折风险增加。本文探讨了益生菌作为预防和管理OP的辅助方法的潜力。已经确定肠道微生物群(GM)，一个复杂的微生物群落，在骨骼健康中起着重要作用。肠道菌群失调与OP的高风险有关。然而,适量食用益生菌可恢复肠道健康，从而改善骨骼健康。益生菌可能通过增强钙吸收影响骨代谢，减少炎症，骨形成增加。动物和人体研究表明，益生菌对骨健康参数的积极影响，如减少破骨细胞生成，骨吸收标记，成骨细胞,骨细胞凋亡,增加骨密度和骨保护素的表达。目前的证据表明，益生菌可以与现有的治疗方法一起用作预防和管理OP的辅助方法。
