Abstract：
Our goal was to assess the impact of childhood/adolescent cancer history on overall survival (OS) and disease-specific survival (DSS) in patients with parotid mucoepidermoid carcinoma (MEC). Patients who underwent surgical treatment for primary parotid MEC and those with a second malignancy of parotid MEC were retrospectively identified from the Surveillance, Epidemiology, and End Results (SEER) database. The primary outcome variables were OS and DSS. The hazard ratios (HRs) of these survival rates associated with cancer history were analysed using Cox regression models. In total, 2681 patients were included, 263 of whom had a second malignancy. The 10-year OS rates in the primary (72%) and second malignancy groups (59%) were significantly different. Cox regression confirmed that a history of cancer tended to decrease OS (p = 0.062, HR: 1.28, 95% confidence interval: 0.99 to 1.64). Subgroup analyses showed that a history of solid tumour as opposed to haematological cancer predicted worse OS, with central nervous system tumours exhibiting a more significant influence than others (p = 0.030 vs p = 0.088). Cancer history was not related to DSS. A history of childhood/adolescent cancer negatively influenced the prognosis of patients with parotid MEC, and this effect was primarily driven by a history of solid malignancy.
摘要：
我们的目标是评估儿童/青少年癌症病史对腮腺粘液表皮样癌（MEC）患者总生存期（OS）和疾病特异性生存期（DSS）的影响。对原发腮腺MEC接受手术治疗的患者和患有腮腺MEC第二恶性肿瘤的患者进行回顾性分析。流行病学,和结束结果(SEER)数据库。主要结果变量是OS和DSS。使用Cox回归模型分析与癌症病史相关的这些生存率的风险比(HR)。总的来说,纳入2681例患者，其中263人患有第二恶性肿瘤。原发性恶性肿瘤组（72％）和第二恶性肿瘤组（59％）的10年OS率存在显着差异。Cox回归证实，癌症史倾向于降低OS（p=0.062，HR：1.28，95％置信区间：0.99至1.64）。亚组分析显示，与血液癌症相比，实体瘤病史预示着OS恶化，中枢神经系统肿瘤比其他肿瘤表现出更显著的影响(p=0.030vsp=0.088)。癌症病史与DSS无关。儿童/青少年癌症病史对腮腺MEC患者的预后有负面影响，这种影响主要是由实体恶性肿瘤病史引起的。
