Abstract：
Tauopathies constitute a group of neurodegenerative diseases characterized by abnormal aggregation of the protein tau, progressive neuronal and synaptic loss, and eventual cognitive and motor impairment. In this review, we will highlight the latest efforts investigating the intricate interplay between the gut microbiome and tauopathies. We discuss the physiological interactions between the microbiome and the brain as well as clinical and experimental evidence that suggests that the presence of tauopathy alters the composition of gut microbiota. We explore both animal and human studies that define causative relationships between the gut microbiome and tauopathy by directly manipulating or transferring gut microbiota. This review highlights future directions into identifying and mechanistically elucidating microbial species causally linked to tauopathies, with an ultimate goal of devising therapeutic targets towards the gut microbiome to treat tauopathies.
摘要：
Tau蛋白病构成一组神经退行性疾病，其特征是tau蛋白的异常聚集，进行性神经元和突触丢失，以及最终的认知和运动障碍。在这次审查中,我们将重点介绍研究肠道微生物组和tau蛋白病之间复杂相互作用的最新努力。我们讨论了微生物组和大脑之间的生理相互作用，以及临床和实验证据，表明tau蛋白病的存在改变了肠道微生物群的组成。我们探索动物和人类研究，通过直接操纵或转移肠道微生物区来定义肠道微生物组和tau蛋白病之间的因果关系。这篇综述强调了未来的方向，以确定和机械地阐明与tau蛋白病有关的微生物物种，最终目标是为肠道微生物组设计治疗靶点以治疗tau蛋白病。
