PDF(Pubmed)
Abstract：
BACKGROUND: Reviewing and updating research priorities is essential to assess progress and to ensure optimal allocation of financial and human resources in research. In 2001, WHO held a research priority setting workshop for herpes simplex virus type 2 (HSV-2) research in low-income and middle-income countries (LMICs). This study aimed to describe progress between 2000 and 2020 in three of the five key research priority areas outlined in the workshop: HSV-2/HIV interactions, HSV-2 control measures and HSV-2 mathematical modelling. The remaining priorities are addressed in a companion paper.
METHODS: A systematic literature search of MEDLINE, CINAHL, Global Health and Cochrane databases was carried out. Relevant primary research studies based in LMICs, written in English and published on 2000-2020 were included. Papers were screened by two independent reviewers, and suitable variables were selected for manual extraction from study texts. Data were organised into an Excel spreadsheet and analysed using IBM SPSS.
RESULTS: In total, 3214 discrete papers were identified, of which 180 were eligible for inclusion (HSV-2/HIV interactions, 98; control measures, 58; mathematical modelling, 24). Most studies were conducted in East Africa. The majority of the 2001 WHO HSV-2 research priorities were addressed at least in part. Overall, despite several studies describing a strong relationship between HSV-2 and the acquisition and transmission of HIV, HSV-2 control repeatedly demonstrated little effect on HIV shedding or transmission. Further, although mathematical modelling predicted that vaccines could significantly impact HSV-2 indicators, HSV-2 vaccine studies were few. Studies of antiviral resistance were also few.
CONCLUSIONS: Since 2000, LMIC HSV-2 research addressing its control, HIV interactions and mathematical modelling has largely addressed the priorities set in the 2001 WHO HSV-2 workshop. However, key knowledge gaps remain in vaccine research, antiviral cost-effectiveness, antiviral resistance and specific geographical areas.
METHODS: A systematic literature search of MEDLINE, CINAHL, Global Health and Cochrane databases was carried out. Relevant primary research studies based in LMICs, written in English and published on 2000-2020 were included. Papers were screened by two independent reviewers, and suitable variables were selected for manual extraction from study texts. Data were organised into an Excel spreadsheet and analysed using IBM SPSS.
RESULTS: In total, 3214 discrete papers were identified, of which 180 were eligible for inclusion (HSV-2/HIV interactions, 98; control measures, 58; mathematical modelling, 24). Most studies were conducted in East Africa. The majority of the 2001 WHO HSV-2 research priorities were addressed at least in part. Overall, despite several studies describing a strong relationship between HSV-2 and the acquisition and transmission of HIV, HSV-2 control repeatedly demonstrated little effect on HIV shedding or transmission. Further, although mathematical modelling predicted that vaccines could significantly impact HSV-2 indicators, HSV-2 vaccine studies were few. Studies of antiviral resistance were also few.
CONCLUSIONS: Since 2000, LMIC HSV-2 research addressing its control, HIV interactions and mathematical modelling has largely addressed the priorities set in the 2001 WHO HSV-2 workshop. However, key knowledge gaps remain in vaccine research, antiviral cost-effectiveness, antiviral resistance and specific geographical areas.
摘要：
背景：审查和更新研究重点对于评估进展并确保在研究中最佳分配财务和人力资源至关重要。2001年，世卫组织为低收入和中等收入国家（LMICs）的2型单纯疱疹病毒（HSV-2）研究举办了一个研究重点确定讲习班。这项研究旨在描述2000年至2020年间研讨会概述的五个关键研究优先领域中的三个领域的进展：HSV-2/HIV相互作用，HSV-2控制措施和HSV-2数学建模。其余的优先事项在一份配套文件中得到解决。
方法：MEDLINE系统文献检索，CINAHL,建立了全球卫生和Cochrane数据库。基于LMIC的相关主要研究研究，包括以英文撰写并于2000-2020年出版的。论文由两名独立审稿人筛选，并选择合适的变量从研究文本中手动提取。将数据组织到Excel电子表格中，并使用IBMSPSS进行分析。
结果：总计，确定了3214篇离散论文，其中180人符合纳入条件(HSV-2/HIV相互作用，98；控制措施，58；数学建模，24).大多数研究是在东非进行的。世卫组织2001年的大多数HSV-2研究优先事项至少部分得到了解决。总的来说,尽管有几项研究描述了HSV-2与HIV的获取和传播之间的密切关系，HSV-2控制反复显示对HIV脱落或传播的影响很小。Further,虽然数学模型预测疫苗会显著影响HSV-2指标，HSV-2疫苗研究很少。抗病毒抗性的研究也很少。
结论：自2000年以来，LMICHSV-2研究解决了其控制问题，艾滋病毒相互作用和数学建模在很大程度上解决了2001年世卫组织HSV-2讲习班确定的优先事项。然而,疫苗研究仍然存在关键知识差距，抗病毒成本效益，抗病毒抗性和特定地理区域。
方法：MEDLINE系统文献检索，CINAHL,建立了全球卫生和Cochrane数据库。基于LMIC的相关主要研究研究，包括以英文撰写并于2000-2020年出版的。论文由两名独立审稿人筛选，并选择合适的变量从研究文本中手动提取。将数据组织到Excel电子表格中，并使用IBMSPSS进行分析。
结果：总计，确定了3214篇离散论文，其中180人符合纳入条件(HSV-2/HIV相互作用，98；控制措施，58；数学建模，24).大多数研究是在东非进行的。世卫组织2001年的大多数HSV-2研究优先事项至少部分得到了解决。总的来说,尽管有几项研究描述了HSV-2与HIV的获取和传播之间的密切关系，HSV-2控制反复显示对HIV脱落或传播的影响很小。Further,虽然数学模型预测疫苗会显著影响HSV-2指标，HSV-2疫苗研究很少。抗病毒抗性的研究也很少。
结论：自2000年以来，LMICHSV-2研究解决了其控制问题，艾滋病毒相互作用和数学建模在很大程度上解决了2001年世卫组织HSV-2讲习班确定的优先事项。然而,疫苗研究仍然存在关键知识差距，抗病毒成本效益，抗病毒抗性和特定地理区域。
