Abstract：
Pleural infection is usually treated with empirical broad-spectrum antibiotics, but limited data exist on their penetrance into the infected pleural space. We performed a pharmacokinetic study analysing the concentration of five intravenous antibiotics across 146 separate time points in 35 patients (amoxicillin, metronidazole, piperacillin-tazobactam, clindamycin and cotrimoxazole). All antibiotics tested, apart from co-trimoxazole, reach pleural fluid levels equivalent to levels within the blood and well above the relevant minimum inhibitory concentrations. The results demonstrate that concerns about the penetration of commonly used antibiotics, apart from co-trimoxazole, into the infected pleural space are unfounded.
摘要：
胸膜感染通常使用经验性广谱抗生素治疗，但是关于它们进入受感染的胸膜腔的数据有限。我们进行了一项药代动力学研究，分析了35例患者的146个不同时间点的五种静脉注射抗生素的浓度（阿莫西林，甲硝唑,哌拉西林他唑巴坦,克林霉素和复方新诺明)。所有抗生素都经过测试，除了复方新诺明,达到相当于血液中水平的胸膜液水平，并且远高于相关的最低抑制浓度。结果表明，对常用抗生素渗透的担忧，除了复方新诺明,进入感染的胸膜腔是没有根据的。
