Abstract：
OBJECTIVE: To pilot test QuitGuide for Natives, a culturally aligned version of the National Cancer Institute\'s QuitGuide smartphone app for smoking cessation.
METHODS: This randomised controlled trial was conducted remotely during 2022-2023. American Indian adults who smoked and resided in the Midwest (n=115) were randomised to QuitGuide for Natives or the general audience QuitGuide smartphone-based intervention. Group differences in feasibility (times the app was initiated), usability, acceptability (\'How likely would you be to recommend the app to a friend?\'), fit of app with culture and preliminary efficacy (24-hour quit attempts, cotinine-confirmed self-reported 7-day abstinence) outcomes were examined.
RESULTS: QuitGuide for Natives versus the general audience QuitGuide did not differ in the number of times the app was opened (adjusted incidence rate ratio 0.94 (95% CI 0.63 to 1.40); p=0.743) nor in usability score (adjusted mean difference (aMD) 0.73 (95% CI: -5.00 to 6.46); p=0.801) or likeliness of recommending the app to a friend (aMD 0.62 (95% CI -0.02 to 1.27); p=0.058). Differences were observed for all cultural fit outcomes such as \'The app fits my American Indian culture (aMD 0.75 (95% CI 0.35 to 1.16); p<0.001). QuitGuide for Natives versus the general audience QuitGuide resulted in an average of 6.6 vs 5.1 24-hour quit attempts (p=0.349) and cotinine-confirmed 7-day abstinence was achieved by 6.9% vs 3.5% (p=0.679).
CONCLUSIONS: Acceptability, cultural fit and preliminary efficacy findings are encouraging and will inform future, larger-scale evaluation of culturally aligned digital smoking cessation resources for American Indian adults.
METHODS: This randomised controlled trial was conducted remotely during 2022-2023. American Indian adults who smoked and resided in the Midwest (n=115) were randomised to QuitGuide for Natives or the general audience QuitGuide smartphone-based intervention. Group differences in feasibility (times the app was initiated), usability, acceptability (\'How likely would you be to recommend the app to a friend?\'), fit of app with culture and preliminary efficacy (24-hour quit attempts, cotinine-confirmed self-reported 7-day abstinence) outcomes were examined.
RESULTS: QuitGuide for Natives versus the general audience QuitGuide did not differ in the number of times the app was opened (adjusted incidence rate ratio 0.94 (95% CI 0.63 to 1.40); p=0.743) nor in usability score (adjusted mean difference (aMD) 0.73 (95% CI: -5.00 to 6.46); p=0.801) or likeliness of recommending the app to a friend (aMD 0.62 (95% CI -0.02 to 1.27); p=0.058). Differences were observed for all cultural fit outcomes such as \'The app fits my American Indian culture (aMD 0.75 (95% CI 0.35 to 1.16); p<0.001). QuitGuide for Natives versus the general audience QuitGuide resulted in an average of 6.6 vs 5.1 24-hour quit attempts (p=0.349) and cotinine-confirmed 7-day abstinence was achieved by 6.9% vs 3.5% (p=0.679).
CONCLUSIONS: Acceptability, cultural fit and preliminary efficacy findings are encouraging and will inform future, larger-scale evaluation of culturally aligned digital smoking cessation resources for American Indian adults.
摘要：
目标：要对土著的QuitGuide进行试点测试，国家癌症研究所的戒烟QuitGuide智能手机应用程序的文化一致版本。
方法：这项随机对照试验在2022-2023年期间远程进行。吸烟并居住在中西部的美洲印第安人成年人（n=115）被随机分配到QuitGuidefor原住民或基于智能手机的普通受众QuitGuide干预。组的可行性差异（应用程序启动的时间），可用性，可接受性（\'您向朋友推荐该应用程序的可能性有多大？\'），应用程序与文化和初步功效的契合(24小时戒烟尝试，检查可替宁确认的自我报告的7天禁欲）结局。
结果：QuitGuideforNativent与普通受众QuitGuide在打开应用程序的次数（调整后的发生率比0.94（95％CI为0.63至1.40）；p=0.743）和可用性得分（调整后的平均差（aMD）0.73（95％CI：-5.00至6.46）；p=0.801）或向朋友推荐的0.02（p-所有文化适合结果均观察到差异，例如\'该应用程序适合我的美洲印第安人文化（aMD0.75（95％CI0.35至1.16）；p<0.001）。土著QuitGuide与普通受众QuitGuide的平均戒烟次数分别为6.6和5.1（p=0.349），可替宁确认的7天禁欲率分别为6.9％和3.5％（p=0.679）。
结论：可接受性，文化契合度和初步疗效发现令人鼓舞，并将为未来提供信息，对美洲印第安人成年人进行文化上一致的数字戒烟资源的更大规模评估。
方法：这项随机对照试验在2022-2023年期间远程进行。吸烟并居住在中西部的美洲印第安人成年人（n=115）被随机分配到QuitGuidefor原住民或基于智能手机的普通受众QuitGuide干预。组的可行性差异（应用程序启动的时间），可用性，可接受性（\'您向朋友推荐该应用程序的可能性有多大？\'），应用程序与文化和初步功效的契合(24小时戒烟尝试，检查可替宁确认的自我报告的7天禁欲）结局。
结果：QuitGuideforNativent与普通受众QuitGuide在打开应用程序的次数（调整后的发生率比0.94（95％CI为0.63至1.40）；p=0.743）和可用性得分（调整后的平均差（aMD）0.73（95％CI：-5.00至6.46）；p=0.801）或向朋友推荐的0.02（p-所有文化适合结果均观察到差异，例如\'该应用程序适合我的美洲印第安人文化（aMD0.75（95％CI0.35至1.16）；p<0.001）。土著QuitGuide与普通受众QuitGuide的平均戒烟次数分别为6.6和5.1（p=0.349），可替宁确认的7天禁欲率分别为6.9％和3.5％（p=0.679）。
结论：可接受性，文化契合度和初步疗效发现令人鼓舞，并将为未来提供信息，对美洲印第安人成年人进行文化上一致的数字戒烟资源的更大规模评估。
