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Abstract：
BACKGROUND: Persistent infection with high-risk human papillomavirus (HPV) is the causal agent of several cancers including cervical, anal and oropharyngeal cancer. Transgender men and transmasculine non-binary (TMNB) people with a cervix are much less likely to undergo cervical cancer screening than cisgender women. Transgender women and transfeminine non-binary (TWNB) people assigned male at birth may be at increased risk of HPV. Both TMNB and TWNB people face many barriers to HPV testing including medical mistrust due to stigma and discrimination.
METHODS: The Self-TI Study (Self-TI) is a pilot study designed to measure acceptability and feasibility of HPV self-testing among transgender and non-binary people in England. TMNB people aged 25-65 years, with at least 1 year of testosterone, and TWNB people, aged 18 years and over, are eligible to participate. Participants self-collect up to four samples: an oral rinse, a first void urine sample, a vaginal swab (if applicable) and an anal swab. TMNB participants are asked to have an additional clinician-collected cervical swab taken following their routine Cervical Screening Programme sample. TWNB people are asked to take a self-collection kit to perform additional self-collection at home and mail the samples back to the clinic. Acceptability is assessed by a self-administered online survey and feasibility is measured as the proportion of samples returned in the clinic and from home.
BACKGROUND: Self-TI received ethical approval from the Research Ethics Committee of Wales 4 and ethical review panel within the Division of Cancer Epidemiology and Genetics at the US National Cancer Institute. Self-TI was coproduced by members of the transgender and non-binary community, who served as authors, collaborators and members of the patient and public involvement (PPI) group. Results of this study will be shared with the community prior to being published in peer-reviewed journals and the PPI group will help to design the results dissemination strategy. The evidence generated from this pilot study could be used to inform a larger, international study of HPV self-testing in the transgender and non-binary community.
BACKGROUND: NCT05883111.
METHODS: The Self-TI Study (Self-TI) is a pilot study designed to measure acceptability and feasibility of HPV self-testing among transgender and non-binary people in England. TMNB people aged 25-65 years, with at least 1 year of testosterone, and TWNB people, aged 18 years and over, are eligible to participate. Participants self-collect up to four samples: an oral rinse, a first void urine sample, a vaginal swab (if applicable) and an anal swab. TMNB participants are asked to have an additional clinician-collected cervical swab taken following their routine Cervical Screening Programme sample. TWNB people are asked to take a self-collection kit to perform additional self-collection at home and mail the samples back to the clinic. Acceptability is assessed by a self-administered online survey and feasibility is measured as the proportion of samples returned in the clinic and from home.
BACKGROUND: Self-TI received ethical approval from the Research Ethics Committee of Wales 4 and ethical review panel within the Division of Cancer Epidemiology and Genetics at the US National Cancer Institute. Self-TI was coproduced by members of the transgender and non-binary community, who served as authors, collaborators and members of the patient and public involvement (PPI) group. Results of this study will be shared with the community prior to being published in peer-reviewed journals and the PPI group will help to design the results dissemination strategy. The evidence generated from this pilot study could be used to inform a larger, international study of HPV self-testing in the transgender and non-binary community.
BACKGROUND: NCT05883111.
摘要：
背景：高危型人乳头瘤病毒（HPV）的持续感染是包括宫颈癌在内的几种癌症的病因。肛门和口咽癌。变性男性和跨男性的非二元（TMBB）子宫颈的人比顺性女性接受宫颈癌筛查的可能性要小得多。出生时被分配为男性的跨性别女性和跨女性非二元（TWNB）人可能会增加HPV的风险。TMNB和TWNB人在HPV检测方面都面临许多障碍，包括由于耻辱和歧视而导致的医疗不信任。
方法：自我TI研究（Self-TI）是一项试点研究，旨在衡量英格兰跨性别和非二元人群中HPV自我检测的可接受性和可行性。25-65岁的TMNB人，至少1年的睾丸激素，和TWNB人，18岁及以上，有资格参加。参与者自我收集多达四个样本：口腔冲洗液，第一个尿液样本，阴道拭子（如果适用）和肛门拭子。TMBB参与者被要求在他们的常规宫颈筛查计划样本后进行额外的临床医生收集的宫颈拭子。TWNB的人被要求采取一个自我收集工具包，在家里进行额外的自我收集，并将样本邮寄回诊所。通过自我管理的在线调查评估可接受性，并通过在诊所和家中返回的样品比例来衡量可行性。
背景：Self-TI获得了威尔士4号研究伦理委员会和美国国家癌症研究所癌症流行病学和遗传学部门伦理审查小组的伦理批准。Self-TI是由变性人和非二元社区的成员共同制作的，作为作者，患者和公众参与（PPI）小组的合作者和成员。这项研究的结果将在发表在同行评审的期刊上之前与社区共享，PPI小组将帮助设计结果传播策略。从这项试点研究中产生的证据可以用来告知更大的，变性人和非二元社区HPV自检的国际研究。
背景：NCT05883111。
方法：自我TI研究（Self-TI）是一项试点研究，旨在衡量英格兰跨性别和非二元人群中HPV自我检测的可接受性和可行性。25-65岁的TMNB人，至少1年的睾丸激素，和TWNB人，18岁及以上，有资格参加。参与者自我收集多达四个样本：口腔冲洗液，第一个尿液样本，阴道拭子（如果适用）和肛门拭子。TMBB参与者被要求在他们的常规宫颈筛查计划样本后进行额外的临床医生收集的宫颈拭子。TWNB的人被要求采取一个自我收集工具包，在家里进行额外的自我收集，并将样本邮寄回诊所。通过自我管理的在线调查评估可接受性，并通过在诊所和家中返回的样品比例来衡量可行性。
背景：Self-TI获得了威尔士4号研究伦理委员会和美国国家癌症研究所癌症流行病学和遗传学部门伦理审查小组的伦理批准。Self-TI是由变性人和非二元社区的成员共同制作的，作为作者，患者和公众参与（PPI）小组的合作者和成员。这项研究的结果将在发表在同行评审的期刊上之前与社区共享，PPI小组将帮助设计结果传播策略。从这项试点研究中产生的证据可以用来告知更大的，变性人和非二元社区HPV自检的国际研究。
背景：NCT05883111。
