Abstract：
OBJECTIVE: The aim of the present study was to determine the methodological quality of systematic reviews that evaluated the effectiveness of pentoxifylline and tocopherol (PENTO) in the treatment of osteoradionecrosis of the jaw (ORNJ) and medication-related osteonecrosis of the jaw (MRONJ).
METHODS: Searches were performed in Databases including PubMed, Scopus, LILACS, DARE, Cochrane Library, and SIGLE through OpenGrey until March 2024, were evaluated by two independent reviewers to answer the following question: Is the use of PENTO protocol effective in the treatment of ORNJ or for the treatment of MRONJ?
RESULTS: A total of 256 articles were initially identified; however, following the use of appropriate inclusion and exclusion criteria, five systematic reviews were identified for detailed analysis. The final study sample comprised 588 patients: 397 patients with ORN and 197 patients with MRONJ who were treated with PENTO. The total recovery of individuals who used the PENTO protocol was 62,2 % for ORN and 100 % for MRONJ, with a follow-up period of 1 month to 10 years. The methodological quality of the studies was assessed using the AMSTAR 2 tool, in which four were of low quality and 1 moderate quality.
CONCLUSIONS: The treatment of ORN and MRONJ with pentoxifylline and tocopherol has shown good results in the studies presented, with a partial or total reduction in bone exposure. However, the low quality of the relevant reports highlights the need for primary and secondary studies with better methodological rigor to reduce bias and provide reassurance for this treatment option.
METHODS: Searches were performed in Databases including PubMed, Scopus, LILACS, DARE, Cochrane Library, and SIGLE through OpenGrey until March 2024, were evaluated by two independent reviewers to answer the following question: Is the use of PENTO protocol effective in the treatment of ORNJ or for the treatment of MRONJ?
RESULTS: A total of 256 articles were initially identified; however, following the use of appropriate inclusion and exclusion criteria, five systematic reviews were identified for detailed analysis. The final study sample comprised 588 patients: 397 patients with ORN and 197 patients with MRONJ who were treated with PENTO. The total recovery of individuals who used the PENTO protocol was 62,2 % for ORN and 100 % for MRONJ, with a follow-up period of 1 month to 10 years. The methodological quality of the studies was assessed using the AMSTAR 2 tool, in which four were of low quality and 1 moderate quality.
CONCLUSIONS: The treatment of ORN and MRONJ with pentoxifylline and tocopherol has shown good results in the studies presented, with a partial or total reduction in bone exposure. However, the low quality of the relevant reports highlights the need for primary and secondary studies with better methodological rigor to reduce bias and provide reassurance for this treatment option.
摘要：
目的：本研究的目的是确定评估己酮可可碱和生育酚（PENTO）治疗颌骨放射骨坏死（ORNJ）和药物相关性颌骨坏死（MRONJ）的有效性的系统评价的方法学质量。
方法：在包括PubMed，Scopus,LILACS,DARE,科克伦图书馆,和SIGLE通过OpenGrey直到2024年3月，由两名独立审稿人进行评估，以回答以下问题：使用PENTO方案对ORNJ或MRONJ的治疗有效吗？
结果：最初总共确定了256篇文章；但是，在使用适当的纳入和排除标准后，我们确定了5篇系统综述进行详细分析.最终的研究样本包括588名患者：397名ORN患者和197名接受PENTO治疗的MRONJ患者。使用PENTO方案的个人的总回收率为ORN的62,2％和MRONJ的100％，随访期为1个月至10年。使用AMSTAR2工具评估研究的方法学质量，其中4个质量低，1个质量中等。
结论：己酮可可碱和生育酚治疗ORN和MRONJ的研究显示出良好的效果，骨暴露部分或全部减少。然而,相关报告的质量较低,这凸显了初级和次级研究需要更好的方法学严谨,以减少偏倚并为这一治疗选择提供保证.
方法：在包括PubMed，Scopus,LILACS,DARE,科克伦图书馆,和SIGLE通过OpenGrey直到2024年3月，由两名独立审稿人进行评估，以回答以下问题：使用PENTO方案对ORNJ或MRONJ的治疗有效吗？
结果：最初总共确定了256篇文章；但是，在使用适当的纳入和排除标准后，我们确定了5篇系统综述进行详细分析.最终的研究样本包括588名患者：397名ORN患者和197名接受PENTO治疗的MRONJ患者。使用PENTO方案的个人的总回收率为ORN的62,2％和MRONJ的100％，随访期为1个月至10年。使用AMSTAR2工具评估研究的方法学质量，其中4个质量低，1个质量中等。
结论：己酮可可碱和生育酚治疗ORN和MRONJ的研究显示出良好的效果，骨暴露部分或全部减少。然而,相关报告的质量较低,这凸显了初级和次级研究需要更好的方法学严谨,以减少偏倚并为这一治疗选择提供保证.
