Abstract：
Feline injection site fibrosarcomas represent a unique challenge in veterinary oncology due to their association with injection sites and aggressive behaviour. The study explores the expression of immune checkpoints programmed cell death protein 1 and programmed cell death ligand 1 in the malignancy, aiming to unravel their potential significance in tumour progression. The study included 31, archival diagnostic specimens of feline fibrosarcomas, located in the common injection sites. The programmed cell death protein 1 and programmed cell death ligand 1 expression in tumour cells and tumour infiltrating lymphocytes were assessed by immunohistochemical methods. Programmed cell death protein 1 and programmed cell death ligand 1 expression were observed in 84% and 81% of cases, respectively. In tumour infiltrating lymphocytes the PD-1 expression was observed in 71% of cases. Notably, higher programmed cell death protein 1 expression correlated with tumour grade and heightened inflammation score, suggesting a potential association with tumour aggressiveness. Similarly, programmed cell death ligand 1 expression exhibited a positive correlation with tumour grade and inflammation score. The observed findings suggest a potential role for programmed cell death protein 1 and programmed cell death ligand 1 in tumour progression and immune response within the tumour microenvironment. Moreover, this study contributes to a deeper understanding of feline injection site fibrosarcoma pathogenesis, emphasizing the importance of considering immunological perspectives in developing effective treatment strategies for this challenging condition. Further investigations are warranted to advance our knowledge and refine therapeutic approaches for feline injection site fibrosarcoma management.
摘要：
猫注射部位纤维肉瘤由于其与注射部位和攻击行为的关联而代表了兽医肿瘤学中的独特挑战。该研究探讨了免疫检查点程序性细胞死亡蛋白1和程序性细胞死亡配体1在恶性肿瘤中的表达，旨在揭示它们在肿瘤进展中的潜在意义。该研究包括31个猫纤维肉瘤的档案诊断标本，位于常见的注射部位。通过免疫组织化学方法评估肿瘤细胞和肿瘤浸润淋巴细胞中的程序性细胞死亡蛋白1和程序性细胞死亡配体1的表达。在84％和81％的病例中观察到程序性细胞死亡蛋白1和程序性细胞死亡配体1的表达，分别。在71％的肿瘤浸润淋巴细胞中观察到PD-1表达。值得注意的是,较高的程序性细胞死亡蛋白1表达与肿瘤分级和炎症评分升高相关，提示与肿瘤侵袭性的潜在关联。同样，程序性细胞死亡配体1表达与肿瘤分级和炎症评分呈正相关。观察到的发现表明程序性细胞死亡蛋白1和程序性细胞死亡配体1在肿瘤微环境中的肿瘤进展和免疫应答中的潜在作用。此外，这项研究有助于更深入地了解猫注射部位纤维肉瘤的发病机制，强调在为这种具有挑战性的疾病制定有效的治疗策略时考虑免疫学观点的重要性。有必要进行进一步的研究，以提高我们的知识并完善猫注射部位纤维肉瘤管理的治疗方法。
