Abstract：
Having a sense of purpose in life predicts better maintenance of cognitive function in older adulthood and reduced risk of mild cognitive impairment (MCI) and dementia. However, little research has examined its influence on the rate of cognitive decline and length of cognitive healthspan. This study evaluated the role of sense of purpose on the risk and timing of transitions between normal cognition, MCI, and dementia. Older adults from the Memory and Aging Project (MAP; n = 1821) and the Health and Retirement Study (HRS; n = 10,542) were followed annually for 19 years and biennially for 12 years, respectively. Multistate survival models assessed whether sense of purpose predicted transitions across normal cognition, MCI, dementia, and death. More purposeful older adults had lower risk of developing MCI (HR = 0.82 in MAP; HR = 0.93 in HRS), higher likelihood of cognitive improvement, and longer cognitively healthy life expectancies. Results suggest sense of purpose may extend the cognitive healthspan.
摘要：
生活中的目标感预示着老年人认知功能的更好维持，并降低轻度认知障碍（MCI）和痴呆症的风险。然而,很少有研究研究它对认知衰退率和认知健康状况的影响。这项研究评估了目的感对正常认知之间过渡的风险和时间的作用，MCI和痴呆症。来自记忆与衰老项目（MAP;n=1821）和健康与退休研究（HRS;n=10,542）的老年人每年随访19年，每两年随访12年，分别。多状态生存模型评估了目的感是否可以预测正常认知之间的转变，MCI痴呆,和死亡。更有目的的老年人患MCI的风险较低（MAP中HR=0.82；HRS中HR=0.93），认知改善的可能性更高，和更长的认知健康预期寿命。结果表明，目的感可能会延长认知健康范围。
