Abstract：
Acute cutaneous lupus erythematosus (ACLE) is closely associated with systemic symptoms in systemic lupus erythematosus (SLE). This study aimed to identify potential biomarkers for ACLE and explore their association with SLE to enable early prediction of ACLE and identify potential treatment targets for the future. In total, 185 SLE-diagnosed patients were enrolled and categorized into two groups: those with ACLE and those without cutaneous involvement. After conducting logistic regression analysis of the differentiating factors, we concluded that tumor necrosis factor-alpha (TNF-α) is an independent risk factor for ACLE. Analysis of the receiver operating characteristic revealed an area under the curve of 0.716 for TNF-α. Additionally, both TNF-α and ACLE are positively correlated with disease activity. TNF-α shows promise as a biomarker for ACLE, and in SLE patients, ACLE may serve as a clear indicator of moderate-to-severe disease activity.
摘要：
急性皮肤红斑狼疮（ACLE）与系统性红斑狼疮（SLE）的全身症状密切相关。这项研究旨在确定ACLE的潜在生物标志物，并探索它们与SLE的关联，以便能够早期预测ACLE并确定未来的潜在治疗目标。总的来说,纳入185例诊断为SLE的患者，分为两组：ACLE患者和无皮肤受累患者。在对差异因素进行Logistic回归分析后，我们得出结论，肿瘤坏死因子-α（TNF-α）是ACLE的独立危险因素。对接收器工作特性的分析显示，TNF-α的曲线下面积为0.716。此外,TNF-α和ACLE均与疾病活动度呈正相关。TNF-α有望作为ACLE的生物标志物，在SLE患者中，ACLE可以作为中度至重度疾病活动的明确指标。
